Cell Signaling Technology is a supplier of research antibodies, known for its high-quality.

Labome organizes over 1652931 million reagents from 295 high-quality suppliers. As of August 8, 2023, the products include antibodies against 18836 human genes, 14155 mouse genes, and 12210 rat genes, ELISA and assay kits for 7491 human genes, 1725 mouse genes, protein and peptide products for 15451 human genes and 2134 mouse genes, cDNA clones, microRNA clones for 19527 human genes and 16862 mouse genes, gene knockdown reagents (siRNA and shRNA constructs) for 19425 human genes and 18624 mouse genes, and inhibitors against or activators for or substrates for 1393 human genes. You can search all those reagents using the search box above.

http://www.cellsignal.com in English.

Besides the English language webiste, Cell Signaling Technology maintains websites for different languages:

• 中文: 赛信通（上海）生物试剂有限公司 http:// www.cst-c.com.cn/
• 日本語: CSTジャパン株式会社 http://www.cstj.co.jp/
• Deutsch: New England Biolabs GmbH http://www.neb-online.de/

For contact and distributor information in other countries, please see CST web page.

Facebook: http://www.facebook.com/cellsignal

CST headquarters is 3 Trask Lane, Danvers, MA 01923, close to Boston, United States, as part of the local Route 128 life science corridor.

CST operates subsidiaries 赛信通（上海）生物试剂有限公司 (上海市浦东南路1101号远东大厦514室) in China and CSTジャパン株式会社 (東京都千代田区内神田1-6-10　笠原ビルディング10階) in Japan.

CST provides primary and secondary antibodies and their conjugated forms, and many types of kits, for example, PathScan ELISA kits, based on their high-quality, highly validated primary antibodies. The kits include those for detecting endogenous levels of the members of various signaling pathways, cytokines and growth factors, and various assay kits for protein activities, immunohistochemical imaging, chromatin IP, cell viability, proliferation and apoptosis, and other cellular activities, as well as siRNA for selected gene targets. It also provided (now discontinued) PathScan antibody array kits such as PathScan RTK Signaling Antibody Array Kit and PathScan Akt Signaling Antibody Array Kit [1], which enable simultaneous detection of multiple proteins involved in specific pathways [1].

Cell Signaling Technology, Inc. (CST) was founded in 1999 by scientists in the Cell Signaling group at New England Biolabs (NEB). CST's founder is Dr. Michael Comb. New England Biolabs was established in 1974 by and owned by Dr. Donald G. Comb. Nobel Laureate Dr. Richard Roberts joined NEB in 1992 and is the Chief Scientific Officer of NEB.

The executive management of CST includes Dr. Michael J. Comb President / Chief Executive Officer, Mr. Fenel Eloi Chief Operating Officer / Chief Financial Officer, and Dr. Roberto Polakiewicz Chief Scientific Officer.

Unlike most reagent companies, CST and its parent company, NEB, maintain rigorous research programs, similar to a research institute or an academic department. Its scientists have published in recent years in Nature Cell Biology [2], Elife [3] among others.

CST develops and maintains PhosphositePlus PTM database (http://www.phosphosite.org/) [4], an online database of protein post-translational modifications (not just protein phosphorylation). NIH grants partially funded the database. It catalogs the protein post-translational modifications from the literature and also from high-throughput screening experiments. It is the most comprehensive and most accessed protein modification database.

Cell Signaling Technology products have been widely used in research and diagnostic laboratories. For example, R Divine et al utilized the Cell Signaling anti-phospho-Akt (S473) (D9E) XP rabbit monoclonal antibody ( 4060) with a ProteinSimple Jess instrument [5]. van de Kooij B et al detected the tyrosine phosphorylation of Ned10 with Cell Signaling Technology rabbit monoclonal anti-phosphotyrosine antibody (Cat 8954) at 1:2000 dilution [6]. Lee YR et al stained tumor paraffin sections with anti-pAKT antibody ( 4060) and anti-cleaved caspase 3 ( 9661) antibodies from CST to study the reactivation of PTEN tumor suppressor [7].

Among those citing Cell Signaling Technology reagents, the top 5 most cited antibodies, without any doubt, are involved in cellular signaling pathways (Table 2). They are AKT antibodies, ERK2 antibodies, ERK1 antibodies, and JNK antibodies. These numbers of publications are those that can be identified by Labome. The actual numbers for each product are much higher. Some of recent examples are listed here. L Zhao et al applied PR A/B ( 3176), GR ( 3660), AKT ( 4691, 4060), P21 ( 2947), β-catenin ( 8480), FoxA1 ( 53528), HER3 ( 4791, 12708), HER2 ( 2247, 4290), caspases ( 9661, 8438, 9496, 9505), cleaved PARP ( 5625) and GAPDH ( 8884) antibodies in western blotting [52]. Kitchen P et al used Cell Signaling anti-calmodulin antibody D1F7J, anti-lamin B1 antibody D4Q4Z and anti-alpha tubulin antibody (2144) for their study of AQP4 in CNS edema [53]. Rhodes JDP et al used its rabbit mAb anti-RING1B antibody ( 5694) for ChIP at 1:1000 and mouse mAb anti-H3S10p antibody (9706) for flow cytometry at 1:25 [54]. Moro A et al used Cell Signaling Technology rabbit monoclonal Ago2 antibody clone C34C6 ( 2897) to label AGO2 in HUVEC lysates and cells in Western blots and immunocytochemistry [55]. Its GAPDH antibodies, used as loading controls, gain popularity rapidly in recent years [55-60]. Anti-HSP90 antibody ( 4874) is also used as a loading control.

Cell Signaling Technology exhibits in many professional meetings like SFN, AACR, and ASCB and also exhibits at the vendor shows in many universities, where visitors can usually obtain the pathway posters, catalogs, samples, and other goodies. Check this show calendar for vendor shows and conferences.

Cell Signaling Technology is located in Danvers, Massachusetts, about 18 miles (29 km) northeast of the major US metropolitan city Boston. As of the 2010 U.S. Census, Danvers had a total population of 26493. The town is known for the 1692 Salem witch trials. The house of the executed "witch" Rebecca Nurse is still standing as a historical landmark.