p130 [Cas] antibody | knockout validation

p130 [Cas] antibody | knockout validation | BD 610271

This is a knockout-validated antibody summary, based on the publication "Mechanical Regulation of Bone Homeostasis Through p130Cas-mediated Alleviation of NF-κB Activity", as cited below [1]. Labome curates formal publications to compile a list of antibodies with unambiguous specificity within Validated Antibody Database (VAD).

Figure 1. Significant reduction of Cas expression in osteocyte fractions derived from Cas cKO mice. From [1].

Antibody information

Mouse monoclonal IgG1

Company: BD

Antibody: p130 [Cas] Catalog number: 610271

Summary: Mouse monoclonal IgG1 against rat p130 [Cas] (aa. 644-819). Reacts with human, mouse, rat, dog, and chicken. Suitable for western blot, immunoprecipitation, immunofluorescence, immunohistochemistry-formalin (antigen retrieval required).

Validation Method

Western blot

Sample

WT and osteocyte-specific Cas conditional knockout mice osteocytes.

References

Miyazaki T, Zhao Z, Ichihara Y, Yoshino D, Imamura T, Sawada K, et al. Mechanical regulation of bone homeostasis through p130Cas-mediated alleviation of NF-κB activity. Sci Adv. 2019;5:eaau7802 pubmed publisher

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