SOX4 antibody | knockout validation | Atlas Antibodies AMAb91380

This is a knockout-validated antibody summary, based on the publication "Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping", as cited below [1]. Labome curates formal publications to compile a list of antibodies with unambiguous specificity within Validated Antibody Database (VAD).

Antibody information

Mouse monoclonal IgG1 against

Company: Atlas Antibodies

Antibody: SOX4

Catalog number: AMAb91380

Summary: Mouse monoclonal IgG1 against a synthetic peptide (AGADPSDPLGLYEEEGAG) corresponding to residues of human SOX4. Reacts with human, mouse and rat. Suitable for immunocytochemistry/immunofluorescence and immunohistochemistry.

Validation Method

Immunohistochemistry

Sample

Small intestine of wild-type and Sox4 KO mice. Intestines were fixed overnight in formalin, dehydrated using ethanol and embedded in paraffin. 4 mm-sections were processed using standard methods and antigen retrieval was performed using citrate buffer (pH 6.0).

Primary incubation

Overnight at 4C.

Detection

Confocal microscope.

Figure

Immunofluorescent co-staining of NEUROG3 and Sox4 in proximal small intestine of wild-type and Sox4 KO mice. Please see Suppl. Figure 7B in the article [1].

Clone note

The same clone (CL5665) is sold as Novus Biologicals NBP2-61421; Invitrogen MA5-31424; Atlas Antibodies AMAb91380.

References
  1. Gehart H, van Es J, Hamer K, Beumer J, Kretzschmar K, Dekkers J, et al. Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping. Cell. 2019;176:1158-1173.e16 pubmed publisher