This is a knockout-validated antibody summary, based on the publication "Deletion of Runx2 in condylar chondrocytes disrupts TMJ tissue homeostasis", as cited below [1]. Labome curates formal publications to compile a list of antibodies with unambiguous specificity within Validated Antibody Database (VAD).
Mouse monoclonal IgG2b
Company: MBL
Antibody: Runx2 (Cbfa1)
Catalog number: D130-3
Summary: Mouse monoclonal IgG2b against recombinant Runx2. Reacts with mouse and human. Suitable for western blot, immunoprecipitation, immunocytochemistry, immunohistochemistry and ELISA.
Immunohistochemistry
Control and Runx2-KO temporomandibular joint cartilage from mice.
1:200 dilution at 4°C overnight.
The IHC results showed that Runx2 expression was detected in proliferative (red arrowheads) and hypertrophic (blue arrowheads) chondrocytes in Cre− control mice, while Runx2 expression was undetectable in these regions in Runx2Agc1CreER KO mice (right panel). Please see Figure 3a in the article [1].
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