Nucleophosmin antibody | knockout validation | Abcam ab10530

This is a knockout-validated antibody summary, based on the publication "A KRAS-responsive long non-coding RNA controls microRNA processing", as cited below [1]. Labome curates formal publications to compile a list of antibodies with unambiguous specificity within Validated Antibody Database (VAD).

Nucleophosmin antibody | knockout validation | Abcam ab10530 figure 1
Figure 1. Immunoblotting showing NPM1 KO in two different CRISPR/Cas9 clones. From [1].
Antibody information

Mouse monoclonal IgG1

Company: Abcam

Antibody: Nucleophosmin

Catalog number: ab10530

Summary: Mouse monoclonal antibody against full length native rat NPM1 protein (purified). The epitope recognized by the antibody lies within the 68 amino acids at the C terminus of B23. Reacts with mouse, rat, cow, dog, human, African green monkey, and Chinese hamster. Suitable for western blot and immunocytochemistry/immunofluorescence.

Validation Method

Western blot

Sample

Control and NPM1-KO H1299 cells.

Primary incubation

1:1,000 dilution.

Secondary incubation

1:5,000 dilution anti-mouse IgG, HRP-linked Antibody (Cell Signaling Technology, 7076).

Detection

Western Bright ECL-Spray substrate and ChemiDoc instrument (Bio-Rad).

Clone note

The same clone (FC82291) is sold as Novus Biologicals NB600-1030; Santa Cruz Biotechnology sc-56622; Abcam ab10530; MilliporeSigma B0556.

References
  1. Shi L, Magee P, Fassan M, Sahoo S, Leong H, LEE D, et al. A KRAS-responsive long non-coding RNA controls microRNA processing. Nat Commun. 2021;12:2038 pubmed publisher