This is a knockout-validated antibody summary, based on the publications "NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component", as cited below [1], and "Novel role for caspase 1 inhibitor VX765 in suppressing NLRP3 inflammasome assembly and atherosclerosis via promoting mitophagy and efferocytosis" for western blot knockout validation (figure 1d) [2]. Labome curates formal publications to compile a list of antibodies with unambiguous specificity within Validated Antibody Database (VAD).
Mouse monoclonal
Company: AdipoGen
Antibody: NLRP3
Catalog number: AG-20B-0014 (cryo-2)
Summary: Mouse monoclonal antibody raised against a recombinant polypeptide corresponding to residues 1-93 of mouse NLRP3.
Supplier recommended for WB, IP, IHC and ChIP.
Reacts with human and mouse NLRP3.
Western blot
Lysates of peritoneal macrophages from wild-type and NLRP3 -/- mice.
Anti-NLRP3 antibody.
See Figure 4 in [1].
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