N-WASP antibody | knockout validation

N-WASP antibody | knockout validation | Cell Signaling 4848

This is a knockout-validated antibody summary, based on the publication "N-WASP Control of LPAR1 Trafficking Establishes Response to Self-Generated LPA Gradients to Promote Pancreatic Cancer Cell Metastasis", as cited below [1]. Labome curates formal publications to compile a list of antibodies with unambiguous specificity within Validated Antibody Database (VAD).

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N-WASP antibody | knockout validation | Cell Signaling 4848 figure 1

Figure 1. Representative haematoxylin and eosin (H&E) (top) and immunohistochemistry (N-WASP) (bottom) stained sections of normal pancreata. From [1].

Antibody information

Rabbit monoclonal IgG

Company: Cell Signaling

Antibody: N-WASP

Catalog number: 4848

Summary: Rabbit monoclonal IgG against a synthetic peptide corresponding to the sequence of human N-WASP. Reacts with bovine, hamster, human, monkey, mouse, and rat. Suitable for western blot and immunoprecipitation.

Validation Method

Immunohistochemistry

Sample

WT and N-WASP-KO mouse pancreas.

Detection

Leica SCN 400f scanner.

References

Juin A, Spence H, Martin K, McGhee E, Neilson M, Cutiongco M, et al. N-WASP Control of LPAR1 Trafficking Establishes Response to Self-Generated LPA Gradients to Promote Pancreatic Cancer Cell Metastasis. Dev Cell. 2019;51:431-445.e7 pubmed publisher

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