This is a knockout-validated antibody summary, based on the publication "Therapeutic Targeting of Preleukemia Cells in a Mouse Model of NPM1 Mutant Acute Myeloid Leukemia", as cited below [1]. Labome curates formal publications to compile a list of antibodies with unambiguous specificity within Validated Antibody Database (VAD).
Rabbit monoclonal IgG
Company: Cell Signaling
Antibody: MLL2/KMT2B
Catalog number: 63735
Summary: Rabbit monoclonal IgG against a synthetic peptide corresponding to residues near the carboxy terminus of human MLL2/KMT2B protein. Reacts with human. Suitable for western blot, immunoprecipitation and immunofluorescence/immunocytochemistry.
Western blot
WT and MLL2-KO OCI-AML3 cells.
Immunoblot validation of Cas9-mediated knock-out of MLL2 in OCI-AML3 cells 5 days after lentiviral transduction with three independent sgRNAs. Please see Figure S8a in the article [1].
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