This is a knockout-validated antibody summary, based on the publication "Deletion of leptin signaling in vagal afferent neurons results in hyperphagia and obesity", as cited below [1]. Labome curates formal publications to compile a list of antibodies with unambiguous specificity within Validated Antibody Database (VAD).

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Figure 1. Immunoreactivity of LepR in nodose ganglia of Nav1.8/LepRfl/fl mice and WT mice. Representative image from 6 animals. From [1].

Company: Santa Cruz Biotechnology

Antibody: LepR

Catalog number: sc-8391

Summary: Mouse monoclonal IgG1 (kappa light chain) specific for an epitope mapping between amino acids 870-894 of short form Ob-R of mouse origin. Recommended for detection of short and long forms of Ob-R of mouse, rat and human origin by western blot, immunoprecipitation, immunofluorescence, immunohistochemistry (paraffin) and ELISA. Also reactive with additional species, including canine.

Immunohistochemistry

nodose ganglia of Nav1.8/LepRfl/fl mice and WT mice

1:100 dilution

If the antibody described in this summary is a polyclonal antibody, since polyclonal antibodies are of limited quantity, please inquire the supplier whether any current polyclonal antibody with the same catalog number is exactly the same as the one described in this summary. Sometimes, different bleeds or different animals are used, usually with a different lot number. In such cases, the result in this summary may not apply to the new antibody with the same catalog number.