HDAC1 antibody | knockout validation

HDAC1 antibody | knockout validation | Cell Signaling 34589

This is a knockout-validated antibody summary, based on the publication "HDAC2 targeting stabilizes the CoREST complex in renal tubular cells and protects against renal ischemia/reperfusion injury", as cited below [1]. Labome curates formal publications to compile a list of antibodies with unambiguous specificity within Validated Antibody Database (VAD).

Figure 1. Western blots using nuclear extracts from primary RTEC cultures from WT B6, HDAC1-/- (H1-/-) and HDAC2-/- mice (H2-/-). From [1].

Antibody information

Rabbit monoclonal IgG

Company: Cell Signaling

Antibody: HDAC1

Catalog number: 34589

Summary: Rabbit monoclonal antibody against a synthetic peptide corresponding to residues surrounding Ala440 of human HDAC1 protein. Reacts with human, mouse, rat, and monkey. Suitable for western blot, immunoprecipitation, immunofluorescence/immunocytochemistry, Chromatin IP, and Chromatin IP-seq.

Validation Method

Western blot

Sample

WT B6 and HDAC1-/- primary renal tubular epithelial cells (RTEC).

References

Aufhauser D, Hernandez P, Concors S, O Brien C, Wang Z, Murken D, et al. HDAC2 targeting stabilizes the CoREST complex in renal tubular cells and protects against renal ischemia/reperfusion injury. Sci Rep. 2021;11:9018 pubmed publisher

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