GATA1 antibody | knockout validation | Santa Cruz sc-266

This is a knockout-validated antibody summary, based on the publication "The PAX-SIX-EYA-DACH network modulates GATA-FOG function in fly hematopoiesis and human erythropoiesis", as cited below [1]. Labome curates formal publications to compile a list of antibodies with unambiguous specificity within Validated Antibody Database (VAD).

Antibody information

Rat monoclonal IgG2a

Company: Santa Cruz

Antibody: GATA1

Catalog number: sc-266

Summary: Rat monoclonal IgG2a against bacterially expressed murine GATA-1. Recommended for detection of GATA-1 of mouse, rat and human origin by western blot, immunoprecipitation and immunofluorescence.

Validation Method

Western blot

Sample

Wild-type and GATA1-KO TF1 cells.

Primary incubation

1:200 dilution.

Secondary incubation

HRP-conjugated secondary antibodies (Jackson ImmunoResearch).

Detection

Enhanced chemiluminescence (ECL; Thermo Fisher Scientific).

Figure

Representative western blot of protein extracts generated from wild-type versus GATA1 KO TF1 cells probed with anti-HBB, anti-GATA1, anti-SIX1 and anti-Actin antibodies. Please see Figure 5c in the article [1].

References
  1. Creed M, Baldeosingh R, Eberly C, Schlee C, Kim M, Cutler J, et al. PAX-SIX-EYA-DACH Network modulates GATA-FOG function in fly hematopoiesis and human erythropoiesis. Development. 2019;: pubmed publisher