GβL antibody | knockout validation | Cell Signaling 3274

This is a knockout-validated antibody summary, based on the publication "TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling", as cited below [1]. Labome curates formal publications to compile a list of antibodies with unambiguous specificity within Validated Antibody Database (VAD).

Antibody information

Rabbit monoclonal IgG

Company: Cell Signaling

Antibody: GβL

Catalog number: 3274

Summary: Rabbit monoclonal IgG against a synthetic peptide corresponding to residues surrounding Gln210 of human GβL. Reacts with human, mouse, rat, and monkey. Suitable for western blot and immunoprecipitation.

Validation Method

Western blot

Sample

GβL+/+ and GβL−/− MEFs.

Primary incubation

1:1,000 dilution.

Secondary incubation

1:3,000 dilution peroxidase-conjugated secondary anti-rabbit (Sigma, A4914) in 5% non-fat milk.

Figure

Immunoblot analysis of whole cell lysates derived from GβL+/+ MEFs or GβL−/− MEFs. Courtesy from the Authors.

References
  1. Wang B, Jie Z, Joo D, Ordureau A, Liu P, Gan W, et al. TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling.. Nature. 2017;545:365-369 pubmed publisher