Cyclin D1 antibody | knockout validation | Abcam ab134175

This is a knockout-validated antibody summary, based on the publication "Extracellular vesicles from neurons promote neural induction of stem cells through cyclin D1", as cited below [1]. Labome curates formal publications to compile a list of antibodies with unambiguous specificity within Validated Antibody Database (VAD).

Cyclin D1 antibody | knockout validation | Abcam ab134175 figure 1
Figure 1. Cyclin D1 was absent from cyclin D1 knockout N2A cells. From [1].
Antibody information

Rabbit monoclonal IgG

Company: Abcam

Antibody: Cyclin D1

Catalog number: ab134175

Summary: Rabbit monoclonal antibody against a synthetic peptide of Cyclin D1. Reacts with mouse, rat and human. Suitable for western blot, immunoprecipitation, immunocytochemistry/immunofluorescence and immunohistochemistry (paraffin).

Validation Method

Western blot

Sample

Control and Cyclin D1 knockout N2A cells.

Primary incubation

At 4°C overnight.

Secondary incubation

HRP-linked IgG from mouse and rabbit (45000682; Fisher Scientific) for 1 h at RT.

Detection

Enhanced chemiluminescence method (Thermo Fisher Scientific) on a ChemiDoc Imaging System (Bio-Rad)

References
  1. Song L, Tian X, Schekman R. Extracellular vesicles from neurons promote neural induction of stem cells through cyclin D1. J Cell Biol. 2021;220: pubmed publisher