This is a knockout-validated antibody summary, based on the publication "β3 integrin is dispensable for conditioned fear and hebbian forms of plasticity in the hippocampus", as cited below [1]. Labome curates formal publications to compile a list of antibodies with unambiguous specificity within Validated Antibody Database (VAD).

Cell Signaling Technology

polyclonal anti Integrin b3

Catalogue No. 4702S

This antibody was validated in ITGb3-KO mice by immunoblotting [1]. Western blot analysis of P2 synaptosome samples prepared from ITGb3+⁄+, ITGb3+⁄- and ITGb3-KO mice using this antibody suggest that this antibody is specific for integrin b3, as integrin b3 expression was not detected in knockout mice.

Figure 1. Integrin b3 expression in wild-type and in ITGb3-KO mice

Technique: WB

Species: C57BL ⁄ 6

Integrin b3 expression was not detected in ITGb3-KO mice (see figure 1).