BD mouse monoclonal Cav-1 antibody 610406 was validated in knockout mice
DOI
http://dx.doi.org/10.13070/ko.en.6.1596
Date
2016-08-31

This is a knockout-validated antibody summary, based on the publication "Caveolin-1 inhibits expression of antioxidant enzymes through direct interaction with nuclear erythroid 2 p45-related factor-2 (Nrf2)", as cited below [1]. Labome curates formal publications to compile a list of antibodies with unambiguous specificity within Validated Antibody Database (VAD).

Antibody information

Company: BD

Antibody: Cav-1

Catalog number: 610406

Summary: Mouse IgG1 raised against RSV-CEF caveolin aa. 1-178. Recommended for the detection of protein from human, mouse, rat, dog, and chicken. Successfully used in western blot, immunohistochemistry, immunoprecipitation, and immunofluorescence.

BD mouse monoclonal Cav-1 antibody 610406 was validated in knockout mice figure 1
Figure 1. Western blot of Cav-1 in wild-type or Cav-1 knock-out mouse fibroblasts were treated with 4-HNE at indicated concentrations for 24 h and were subjected for Western blot analysis of GCLC and HO-1 from figure 1 [1].
Validation Method

WB, western blot

Sample

mouse lung fibroblasts from Cav-1 knock-out mice

References
  1. Li W, Liu H, Zhou J, Cao J, Zhou X, Choi A, et al. Caveolin-1 inhibits expression of antioxidant enzymes through direct interaction with nuclear erythroid 2 p45-related factor-2 (Nrf2). J Biol Chem. 2012;287:20922-30 pubmed publisher