This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Tocris Bioscience
product type :
chemical
product name :
JK 184
catalog :
3341/50
quantity :
50 mg
price :
705 USD
product information
CHEMISTRY :
CC2=C(C3=CSC(NC4=CC=C(OCC)C=C4)=N3)N1C=CC=CC1=N2
Stock Reference :
3341/50
Cat Number :
3341
Product Name :
JK 184
Cas Number :
[315703-52-7]
Unit Size :
50 mg
Size :
50
Unit :
mg
USD :
705 USD
Primary Category :
Enzymes
Secondary Category :
Dehydrogenases
Tertiary Category :
Alcohol Dehydrogenase
Primary Action :
Alcohol dehydrogenase 7 inhibitor; inhibits downstream Hh signaling pathway
Biological Description :
Potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM). Exhibits antiproliferative activity in a range of cancer cell lines (GI50 = 3 - 21 nM) and in human xenografts in vivo. Inhibits alcohol dehydrogenase 7 (Adh7) (IC50 = 210 nM) and acts as a microtubule depolymerizing agent in vitro.
Storage :
Store at +4°C
Formula :
C19H18N4OS
Molwt :
350.44
Minimum Purity :
> 99%
Solubility :
Soluble to 100 mM in DMSO and to 25 mM in ethanol
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
www.tocris.com
800-343-7475
headquarters: UK