Costunolide | Tocris Bioscience 2483/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Costunolide

catalog :

2483/10

quantity :

10 mg

price :

182 USD

citations: 5

Reference
Liu Q, Beyraghdar Kashkooli A, Manzano D, Pateraki I, Richard L, Kolkman P, et al. Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity. Nat Commun. 2018;9:4657 pubmed publisher
Ahmad F, Patrick S, Sheikh T, Sharma V, Pathak P, Malgulwar P, et al. Telomerase reverse transcriptase (TERT) - enhancer of zeste homolog 2 (EZH2) network regulates lipid metabolism and DNA damage responses in glioblastoma. J Neurochem. 2017;143:671-683 pubmed publisher
Ahmad F, Dixit D, Sharma V, Kumar A, Joshi S, Sarkar C, et al. Nrf2-driven TERT regulates pentose phosphate pathway in glioblastoma. Cell Death Dis. 2016;7:e2213 pubmed publisher
Ramirez A, Saillard N, Yang T, Franssen M, Bouwmeester H, Jongsma M. Biosynthesis of sesquiterpene lactones in pyrethrum (Tanacetum cinerariifolium). PLoS ONE. 2013;8:e65030 pubmed publisher
Liu Q, Majdi M, Cankar K, Goedbloed M, Charnikhova T, Verstappen F, et al. Reconstitution of the costunolide biosynthetic pathway in yeast and Nicotiana benthamiana. PLoS ONE. 2011;6:e23255 pubmed publisher

product information

brand :

Tocris

master code :

2483

SKU :

2483/10

product name :

Costunolide

description :

Inhibitor of human telomerase activity

target :

Telomerase Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

97%

observed molecular weight :

232.32

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Costunolide is an inhibitor of human telomerase activity (IC50 = 65 u M in MCF-7 breast cancer cells). Suppresses proliferation and induces apoptosis in a variety of human tumor cell lines. Selectively blocks endothelial cell proliferation induced by VEGF. Inhibits expression of iNOS and IL-1 and disrupts NF- B activation. Displays anti-inflammatory, antifungal and antiviral properties.

catalog number base :

2483

extended description :

Inhibitor of human telomerase activity

chemical name text :

(3aS,6E,10E,11aR)-3a,4,5,8,9,11a-Hexahydro-6,10-dimethyl-3-methylene-cyclodeca[b]furan-2(3H)-one

formula :

C 15 H 20 O 2

formula text :

C15H20O2

cas num :

553-21-9

USD 2021 :

175

USD 2022 :

182 USD

product details :

Inhibitor of human telomerase activity

storage :

Store at -20°C