AG 490 | Tocris Bioscience 0414/50 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AG 490

catalog :

0414/50

quantity :

50 mg

price :

556 USD

citations: 14

Reference
Azad A, Yin Lim S, D Costa Z, Jones K, Diana A, Sansom O, et al. PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy. EMBO Mol Med. 2017;9:167-180 pubmed publisher
Rogers S, Gahring L. Upregulation of Nicotinic Acetylcholine Receptor alph4+beta2 through a Ligand-Independent PI3Kbeta Mechanism That Is Enhanced by TNFalpha and the Jak2/p38Mapk Pathways. PLoS ONE. 2015;10:e0143319 pubmed publisher
Zhao L, Li J, Liao K, Luo N, Shi Q, Feng Z, et al. Evodiamine Induces Apoptosis and Inhibits Migration of HCT-116 Human Colorectal Cancer Cells. Int J Mol Sci. 2015;16:27411-21 pubmed publisher
Jiang W, Ye L, Ruge F, Owen S, Martin T, Sun P, et al. YangZheng XiaoJi exerts anti-tumour growth effects by antagonising the effects of HGF and its receptor, cMET, in human lung cancer cells. J Transl Med. 2015;13:280 pubmed publisher
Tactacan C, Phua Y, Liu L, Zhang L, Humphrey E, Cowley M, et al. The pseudokinase SgK223 promotes invasion of pancreatic ductal epithelial cells through JAK1/Stat3 signaling. Mol Cancer. 2015;14:139 pubmed publisher
Shenoy A, Danial M, Blelloch R. Let-7 and miR-125 cooperate to prime progenitors for astrogliogenesis. EMBO J. 2015;34:1180-94 pubmed publisher
Kubota H, Nagao S, Obata K, Hirono M. mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways. PLoS ONE. 2014;9:e106316 pubmed publisher
Park S, Shin E, Min S, An J, Li Z, Hee Chung Y, et al. Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging. Neuropsychopharmacology. 2013;38:1426-37 pubmed publisher
Doulatov S, Notta F, Rice K, Howell L, Zelent A, Licht J, et al. PLZF is a regulator of homeostatic and cytokine-induced myeloid development. Genes Dev. 2009;23:2076-87 pubmed publisher
Fontaine R, Cases O, Lelievre V, Mesples B, Renauld J, Loron G, et al. IL-9/IL-9 receptor signaling selectively protects cortical neurons against developmental apoptosis. Cell Death Differ. 2008;15:1542-52 pubmed publisher
Lu Y, Zhou J, Xu C, Lin H, Xiao J, Wang Z, et al. JAK/STAT and PI3K/AKT pathways form a mutual transactivation loop and afford resistance to oxidative stress-induced apoptosis in cardiomyocytes. Cell Physiol Biochem. 2008;21:305-14 pubmed publisher
Jung S, Yang W, Kim J, Kim H, Kim E, Yun H, et al. Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells. Carcinogenesis. 2008;29:713-21 pubmed publisher
Gross E, Hsu A, Gross G. The JAK/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3 beta. Am J Physiol Heart Circ Physiol. 2006;291:H827-34 pubmed
Bellik L, Vinci M, Filippi S, Ledda F, Parenti A. Intracellular pathways triggered by the selective FLT-1-agonist placental growth factor in vascular smooth muscle cells exposed to hypoxia. Br J Pharmacol. 2005;146:568-75 pubmed

product information

brand :

Tocris

master code :

414

SKU :

0414/50

product name :

AG 490

description :

EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor

target :

EGF Receptor Inhibitors

category :

Small Molecules

unit size :

50 mg

purity :

99%

observed molecular weight :

294.31

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AG 490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 u M for EGFR and ErbB2 respectively). Inhibitor of JAK2, JAK3/STAT, JAK3/AP-1 and JAK3/MAPK pathways and potently inhibits cytokine-independent cell growth in vitro and tumor cell invasion in vivo .

catalog number base :

414

extended description :

EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor

chemical name text :

(E)-2-Cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenamide

formula :

C 17 H 14 N 2 O 3

formula text :

C17H14N2O3

cas num :

133550-30-8

USD 2021 :

520

USD 2022 :

556 USD

product details :

EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor

atl names :

Tyrphostin AG 490

storage :

Store at RT