(-)-Bicuculline methobromide | Tocris Bioscience 0109/50 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

(-)-Bicuculline methobromide

catalog :

0109/50

quantity :

50 mg

price :

490 USD

citations: 15

Reference
Nam M, Han K, Lee J, Won W, Koh W, Bae J, et al. Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference. Cell Rep. 2019;28:1154-1166.e5 pubmed publisher
Woo J, Han Y, Koh W, Won J, Park M, An H, et al. Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient. Exp Neurobiol. 2019;28:30-42 pubmed publisher
Chen G, Zhang Y, Li X, Zhao X, Ye Q, Lin Y, et al. Distinct Inhibitory Circuits Orchestrate Cortical beta and gamma Band Oscillations. Neuron. 2017;96:1403-1418.e6 pubmed publisher
Andrade Talavera Y, Duque Feria P, Paulsen O, Rodríguez Moreno A. Presynaptic Spike Timing-Dependent Long-Term Depression in the Mouse Hippocampus. Cereb Cortex. 2016;26:3637-3654 pubmed publisher
GalvÃ¡n E, PÃ©rez Rosello T, GÃ³mez Lira G, Lara E, GutiÃ©rrez R, Barrionuevo G. Synapse-specific compartmentalization of signaling cascades for LTP induction in CA3 interneurons. Neuroscience. 2015;290:332-45 pubmed publisher
Maccione A, Hennig M, Gandolfo M, Muthmann O, van Coppenhagen J, Eglen S, et al. Following the ontogeny of retinal waves: pan-retinal recordings of population dynamics in the neonatal mouse. J Physiol. 2014;592:1545-63 pubmed publisher
Maguire E, Mitchell E, Greig S, Corteen N, Balfour D, Swinny J, et al. Extrasynaptic glycine receptors of rodent dorsal raphe serotonergic neurons: a sensitive target for ethanol. Neuropsychopharmacology. 2014;39:1232-44 pubmed publisher
Johnson K, Niswender C, Conn P, Xiang Z. Activation of group II metabotropic glutamate receptors induces long-term depression of excitatory synaptic transmission in the substantia nigra pars reticulata. Neurosci Lett. 2011;504:102-106 pubmed publisher
Peng Y, Zeng S, Song H, Li M, Yamada M, Yu X. Postsynaptic spiking homeostatically induces cell-autonomous regulation of inhibitory inputs via retrograde signaling. J Neurosci. 2010;30:16220-31 pubmed publisher
Galvan E, Cosgrove K, Mauna J, Card J, Thiels E, Meriney S, et al. Critical involvement of postsynaptic protein kinase activation in long-term potentiation at hippocampal mossy fiber synapses on CA3 interneurons. J Neurosci. 2010;30:2844-55 pubmed publisher
Sipilä S, Huttu K, Yamada J, Afzalov R, Voipio J, Blaesse P, et al. Compensatory enhancement of intrinsic spiking upon NKCC1 disruption in neonatal hippocampus. J Neurosci. 2009;29:6982-8 pubmed publisher
Huang Y, Hessler N. Social modulation during songbird courtship potentiates midbrain dopaminergic neurons. PLoS ONE. 2008;3:e3281 pubmed publisher
Krook Magnuson E, Li P, Paluszkiewicz S, Huntsman M. Tonically active inhibition selectively controls feedforward circuits in mouse barrel cortex. J Neurophysiol. 2008;100:932-44 pubmed publisher
Miyazato M, Sasatomi K, Hiragata S, Sugaya K, Chancellor M, de Groat W, et al. GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats. J Urol. 2008;179:1178-83 pubmed publisher
Gascon E, Dayer A, Sauvain M, Potter G, Jenny B, De Roo M, et al. GABA regulates dendritic growth by stabilizing lamellipodia in newly generated interneurons of the olfactory bulb. J Neurosci. 2006;26:12956-66 pubmed

product information

brand :

Tocris

master code :

109

SKU :

0109/50

product name :

(-)-Bicuculline methobromide

description :

GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)

target :

GABA-A Receptor Antagonists

category :

Small Molecules

unit size :

50 mg

purity :

98%

observed molecular weight :

462.3

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

(-)-Bicuculline methobromide is a methobromide salt of (+)-bicuculline . Water soluble and more stable than bicuculline. Non-GABA receptor-mediated actions reported. . Methoiodide Salt and Methochloride Salt also available.

catalog number base :

109

extended description :

GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)

chemical name text :

[R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide

formula :

C 21 H 20 BrNO 6

formula text :

C21H20BrNO6

cas num :

66016-70-4

USD 2021 :

458

USD 2022 :

490 USD

product details :

GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)

storage :

Store at RT