HIF Prolylhydroxylase 3 Polyclonal Antibody | Invitrogen PA1-16564 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon

product type :

antibody

product name :

HIF Prolylhydroxylase 3 Polyclonal Antibody

catalog :

PA1-16564

quantity :

100 µl

price :

US 338

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

product information

Product Type :

PA1-16564

Product Name :

HIF Prolylhydroxylase 3 Polyclonal Antibody

Catalog # :

PA1-16564

Quantity :

100 µl

Price :

US 338

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Non-human primate, Rat

Applications :

ChIP assay, Immunoprecipitation and Western Blot

Species :

Hu, Ms, Nhp, Rt

Gene Identification :

Entrez: 112399, 112407, 54702; Uniprot: Q9H6Z9, Q91UZ4, Q62630

Storage :

4° C, do not freeze

Description :

HIF prolyl hydroxylase 3 is a prolyl hydroxylase that modifies HIF-alpha. Classic prolyl hydroxylases are found in the endoplasmic reticulum and modify collagen, whereas HIF is an intracellular protein and the HPH sites do not resemble those modifying collagen. HIF is a transcriptional complex that plays a critical role in oxygen homeostasis. HPH is an essential component of the pathway through which cells sense oxygen. In the presence of oxygen, HPHs convert specific prolyl residues in HIF-alpha to hydroxyproline, leading to HIF-alpha destruction. Low oxygen levels, sensed at the cellular level, cause the HIF conversion to be reduced so that HIF is stable and there is increased angiogenesis. HIF prolyl hydroxylase 1, specifically, catalyzes the posttranslational formation of 4-hydroxyproline in HIF alpha proteins. It hydroxylates HIF-1 alpha at Pro(564) and HIF-2 alpha. It targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex. It may also play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissues, promoting cell death through a caspase-dependent mechanism.

Immunogen :

A synthetic peptide made to the C-terminus of the human protein sequence of HIF prolyl hydroxylase 3.[LocusLink ID 112399]

Format :

Liquid; citric acid, 0.09 % sodium azide

Applications w/Dilutions :

WB 1:500-1:2000, IP 1:10-1:500, ChIP Assay-Dependent

Aliases :

EGL9 homolog of C. elegans 3, EGLN3, Factor responsive smooth muscle protein, HIF Prolyl Hydroxylase 3, HIFP4H3, HIFPH3, P4H3, Prolyl Hydroxylase Doma