Phospho-Integrin beta-3 pTyr785 Polyclonal Antibody | Invitrogen OPA1-03180 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon

product type :

antibody

product name :

Phospho-Integrin beta-3 pTyr785 Polyclonal Antibody

catalog :

OPA1-03180

quantity :

100 µl

price :

US 299

clonality :

polyclonal

host :

rabbit

antigen modification :

phosphorylated

reactivity :

human

application :

western blot

product information

Product Type :

OPA1-03180

Product Name :

Phospho-Integrin beta-3 pTyr785 Polyclonal Antibody

Catalog # :

OPA1-03180

Quantity :

100 µl

Price :

US 299

Clonality :

Polyclonal

Purity :

purified

Host :

Rabbit

Reactivity :

Human

Applications :

Western Blot

Species :

Gene Identification :

Entrez: 3690; Uniprot: P05106

Storage :

-80° C, Avoid Freeze/Thaw Cycles

Description :

Integrin beta3, also known as CD61, is a 130 kDa transmembrane glycoprotein that binds noncovalently in complexes with integrin alpha subunits to form the functional receptor that binds to specific extracellular matrix proteins (e.g., fibronectin, vitronectin, etc.). Integrin receptors are involved in the regulation of a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. The clustering of integrin receptors on the cell surface and their binding to the extracellular matrix leads to the formation of focal contacts and the activation of various signal transduction pathways. Phosphorylation of tyrosine 773 on Integrin beta3 activates the receptor and promotes cell adhesion. Tyr773 is commonly referred to as Tyr747, the corresponding site in the chicken Integrin beta3 protein.

Immunogen :

Synthetic phosphopeptide derived from a region of human integrin beta3 that contains tyrosine 785.

Format :

Liquid; PBS with 1 mg/ml BSA, 0.05 % sodium azide

Applications w/Dilutions :

WB 1:1,000

Aliases :

CD61, GP3A, HPA 1, HPA 4, ITGB3, NAIT , Platelet fibrinogen receptor beta subunit, platelet glycoprotein IIIa precursor, PTP