Cdk2 Monoclonal Antibody (2B6) | Invitrogen MA5-13479 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon

product type :

antibody

product name :

Cdk2 Monoclonal Antibody (2B6)

catalog :

MA5-13479

quantity :

500 ul

price :

US 324

clonality :

monoclonal

host :

mouse

reactivity :

hamsters, African green monkey, human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

citations: 17

immunohistochemistry - paraffin section; human; 1:300	Kiszner G, Wichmann B, Nemeth I, Varga E, Meggyeshazi N, Teleki I, et al. Cell cycle analysis can differentiate thin melanomas from dysplastic nevi and reveals accelerated replication in thick melanomas. Virchows Arch. 2014;464:603-12 pubmed publisher
	Raynaud F, Whittaker S, Fischer P, McClue S, Walton M, Barrie S, et al. In vitro and in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202. Clin Cancer Res. 2005;11:4875-87 pubmed
	Santos C, Rodriguez-Pinilla M, Vega F, Rodriguez-Peralto J, Blanco S, Sevilla A, et al. VRK1 signaling pathway in the context of the proliferation phenotype in head and neck squamous cell carcinoma. Mol Cancer Res. 2006;4:177-85 pubmed
	Yang X, Liu J, Ye L, Liao Q, Wu J, Gao J, et al. HCV NS2 protein inhibits cell proliferation and induces cell cycle arrest in the S-phase in mammalian cells through down-regulation of cyclin A expression. Virus Res. 2006;121:134-43 pubmed
	Cameron R, Liu C, Mixon A, Pihkala J, Rahn R, Cameron P. Myosin16b: The COOH-tail region directs localization to the nucleus and overexpression delays S-phase progression. Cell Motil Cytoskeleton. 2007;64:19-48 pubmed
	Hudson T, Hartle D, Hursting S, Nunez N, Wang T, Young H, et al. Inhibition of prostate cancer growth by muscadine grape skin extract and resveratrol through distinct mechanisms. Cancer Res. 2007;67:8396-405 pubmed
	Nakamura N, Yamamoto H, Yao T, Oda Y, Nishiyama K, Imamura M, et al. Prognostic significance of expressions of cell-cycle regulatory proteins in gastrointestinal stromal tumor and the relevance of the risk grade. Hum Pathol. 2005;36:828-37 pubmed
	Hatjiharissi E, Ngo H, Leontovich A, Leleu X, Timm M, Melhem M, et al. Proteomic analysis of waldenstrom macroglobulinemia. Cancer Res. 2007;67:3777-84 pubmed
	Kutz H, Reisbach G, Schultheiss U, Kieser A. The c-Jun N-terminal kinase pathway is critical for cell transformation by the latent membrane protein 1 of Epstein-Barr virus. Virology. 2008;371:246-56 pubmed
	Zhang Y, Xu P, Park K, Choi Y, Moore D, Wang L. Orphan receptor small heterodimer partner suppresses tumorigenesis by modulating cyclin D1 expression and cellular proliferation. Hepatology. 2008;48:289-98 pubmed publisher
	Shukla S, Gupta S. Apigenin-induced cell cycle arrest is mediated by modulation of MAPK, PI3K-Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human prostate cancer cells. Cell Cycle. 2007;6:1102-14 pubmed
	Haraguchi T, Koujin T, Osakada H, Kojidani T, Mori C, Masuda H, et al. Nuclear localization of barrier-to-autointegration factor is correlated with progression of S phase in human cells. J Cell Sci. 2007;120:1967-77 pubmed
	Weroha S, Li S, Tawfik O, Li J. Overexpression of cyclins D1 and D3 during estrogen-induced breast oncogenesis in female ACI rats. Carcinogenesis. 2006;27:491-8 pubmed
	Lai M, Chen T, Pang S, Yeh C. Overexpression of cyclin-dependent kinase-associated protein phosphatase enhances cell proliferation in renal cancer cells. Urol Oncol. 2012;30:871-8 pubmed publisher
	Sansregret L, Goulet B, Harada R, Wilson B, Leduy L, Bertoglio J, et al. The p110 isoform of the CDP/Cux transcription factor accelerates entry into S phase. Mol Cell Biol. 2006;26:2441-55 pubmed
	Palacios J, Honrado E, Osorio A, Cazorla A, Sarrio D, Barroso A, et al. Phenotypic characterization of BRCA1 and BRCA2 tumors based in a tissue microarray study with 37 immunohistochemical markers. Breast Cancer Res Treat. 2005;90:5-14 pubmed
	Santaguida M, Nepveu A. Differential regulation of CDP/Cux p110 by cyclin A/Cdk2 and cyclin A/Cdk1. J Biol Chem. 2005;280:32712-21 pubmed

product information

Product Type :

MA5-13479

Product Name :

Cdk2 Monoclonal Antibody (2B6)

Catalog # :

MA5-13479

Quantity :

500 ul

Price :

US 324

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Immunofluorescence, Immunohistochemistry (Paraffin) and Western Blot

Species :

Hu, Ms, Rt

Clone :

2B6

Gene Identification :

Entrez: 1017, 12566, 362817; Uniprot: P24941, P97377, Q63699

Isotype :

IgG2b

Storage :

4° C

Description :

p33cdk2 associates with cyclin A in human cells. Kinase activity associated with cyclin A-cdc2 is found only in G2-phase. Cdk2 also complexes with cyclins E, D1, and D3. Cyclin E-cdk2 kinase is active in the G1- and S-phases of the cell cycle and is important (as does cyclin A-cdk2) for the progression from G1-to S-phase. The levels of cyclin A-cdk2 is maximal at the G1/S transition and both cdk2 and cyclin A are found associated with DNA in the initiation complex during replication. Rb protein acts as substrate for cdk2-cyclin E and/or cdk2-cyclin A in vivo. Cdk2 is activated and specifically localized to the nucleus during late G1-, S-, and G2-phase.

Immunogen :

Human recombinant cdk2 protein

Format :

Liquid; PBS with 0.2 % BSA, 0.09 % sodium azide

Applications w/Dilutions :

IF Assay Dependent, IHC (P) 1:25-50, WB 1-2 µg/ml

Aliases :

cdc2-related protein kinase, cell devision kinase 2, cell division protein kinase 2, p33 protein kinase

PubMed References :

18537191, 12393683, 15456744, 16797769, 17440091, 17519288, 16508018, 14729633, 14742266, 16000586, 16084954, 16311245, 12745075, 17029291