I-Ab Monoclonal Antibody (IBL-3/5) | Invitrogen MA1-81017 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

I-Ab Monoclonal Antibody (IBL-3/5)

catalog :

MA1-81017

quantity :

2 mL

price :

279 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

IBL-3/5

reactivity :

human, mouse

application :

immunohistochemistry, flow cytometry, immunohistochemistry - frozen section

citations: 1

Published Application/Species/Sample/Dilution	Reference
ELISA; human	Saffar A, Alphonse M, Shan L, Hayglass K, Simons F, Gounni A. IgE modulates neutrophil survival in asthma: role of mitochondrial pathway. J Immunol. 2007;178:2535-41 pubmed

product information

Product Type :

Antibody

Product Name :

I-Ab Monoclonal Antibody (IBL-3/5)

Catalog # :

MA1-81017

Quantity :

2 mL

Price :

279 USD

Clonality :

Monoclonal

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 1:5, Immunohistochemistry (Frozen): Neat

Species :

Mouse

Clone :

IBL-3/5

Isotype :

IgM

Storage :

4°C or -20°C if preferred

Description :

HLA-DQB1 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.

Immunogen :

in vivo stimulated, purified murine B cells.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:5, Immunohistochemistry (Frozen): Neat

Aliases :

DADB-249P12.2, CELIAC1, HLA-DQB, IDDM1