LAMP-1 / CD107a Monoclonal Antibody (LY1C6) | Invitrogen MA1-25620 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon

product type :

antibody

product name :

LAMP-1 / CD107a Monoclonal Antibody (LY1C6)

catalog :

MA1-25620

quantity :

50 µg

price :

US 360

clonality :

monoclonal

host :

mouse

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry

citations: 1

Steuble M, Gerrits B, Ludwig A, Mateos J, Diep T, Tagaya M, et al. Molecular characterization of a trafficking organelle: dissecting the axonal paths of calsyntenin-1 transport vesicles. Proteomics. 2010;10:3775-88 pubmed publisher

product information

Product Type :

MA1-25620

Product Name :

LAMP-1 / CD107a Monoclonal Antibody (LY1C6)

Catalog # :

MA1-25620

Quantity :

50 µg

Price :

US 360

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Hamster, Human, Mouse, Rat

Applications :

Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot

Species :

Hm, Hu, Ms, Rt

Clone :

LY1C6

Gene Identification :

Entrez: 3916, 16783, 25328; Uniprot: P11279, P11438, P14562

Isotype :

IgG1

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

Lysosome associated membrane proteins (LAMP1), also known as Igp 120 or IgpA, is a type 1 intergral membrane protein that is transported from trans-Golgi network to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboyxl-terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1. This mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly invovled in the adhesion of PBMC to the site of inflammation.

Immunogen :

Rat liver lysosomal membrane preparations.

Format :

Liquid; PBS with 50 % glycerol, 0.1 mM PMSF, no preservative

Applications w/Dilutions :

IHC Assay-dependent, ICC 1:100-1:750, IP 5 µg/ml, WB 1 µg/ml, IF 1:100-1:750

Aliases :

CD107a, LAMPA, LGP120, CD107 antigen-like family member A, LAMP-1, lysosome-associated membrane glycoprotein 1, lysosome-associated membrane protein 1

PubMed References :

20925061