MSH2 Monoclonal Antibody (2MSH01) | Invitrogen MA1-12621 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MSH2 Monoclonal Antibody (2MSH01)

catalog :

MA1-12621

quantity :

500µL

price :

US 459

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2MSH01

reactivity :

human

application :

immunohistochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 5

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; 1:100	Stoehr C, Burger M, Stoehr R, Bertz S, Ruemmele P, Hofstaedter F, et al. Mismatch repair proteins hMLH1 and hMSH2 are differently expressed in the three main subtypes of sporadic renal cell carcinoma. Pathobiology. 2012;79:162-8 pubmed publisher
immunohistochemistry; human; 1:25	Erdamar S, Ucaryilmaz E, Demir G, Karahasanoglu T, Dogusoy G, Dirican A, et al. Importance of MutL homologue MLH1 and MutS homologue MSH2 expression in Turkish patients with sporadic colorectal cancer. World J Gastroenterol. 2007;13:4437-44 pubmed
immunohistochemistry; human; 1:25	Burger M, Denzinger S, Hammerschmied C, Tannapfel A, Obermann E, Wieland W, et al. Elevated microsatellite alterations at selected tetranucleotides (EMAST) and mismatch repair gene expression in prostate cancer. J Mol Med (Berl). 2006;84:833-41 pubmed
immunohistochemistry; human; 1:100	Tanyi M, Olasz J, Lukács G, Csuka O, Toth L, Szentirmay Z, et al. Pedigree and genetic analysis of a novel mutation carrier patient suffering from hereditary nonpolyposis colorectal cancer. World J Gastroenterol. 2006;12:1192-7 pubmed
	Singer G, Kallinowski T, Hartmann A, Dietmaier W, Wild P, Schraml P, et al. Different types of microsatellite instability in ovarian carcinoma. Int J Cancer. 2004;112:643-6 pubmed

product information

Product Type :

Antibody

Product Name :

MSH2 Monoclonal Antibody (2MSH01)

Catalog # :

MA1-12621

Quantity :

500µL

Price :

US 459

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Human

Applications :

Immunohistochemistry (Frozen): Assay Dependent, Immunohistochemistry (Paraffin): Assay Dependent

Species :

Human

Clone :

2MSH01

Isotype :

IgG1

Storage :

4° C, do not freeze

Description :

MSH2 is involved in DNA repair as a mismatch repair protein, and mutations of MSH2 are found in approximately 50% of inherited non polyposis colorectal carcinoma. Defects in MSH2 are a cause of hereditary non-polyposis colorectal cancer (HNPCC) (Lynch syndrome). HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. it is characterized by a familial predisposition to early onset colorectal carcinoma (crc) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the western world.

Immunogen :

Recombinant human MSH2 protein.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Frozen): Assay Dependent, Immunohistochemistry (Paraffin): Assay Dependent

Aliases :

COCA1, FCC1, HNPCC, HNPCC1