product summary
request information :
company name :
Thermo Scientific Pierce Products
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, ABgene, Affinity BioReagents, Nunc
product type :
product name :
CD61 / Integrin beta 3 Monoclonal Antibody, PE conjugate (43.PL)
catalog :
quantity :
100 Tests
price :
US 255
clonality :
host :
reactivity :
application :
FACS, flow cytometry
product information
Product Type :
Product Name :
CD61 / Integrin beta 3 Monoclonal Antibody, PE conjugate (43.PL)
Catalog # :
Quantity :
100 Tests
Price :
US 255
Clonality :
Purity :
Protein A/G
Host :
Reactivity :
Applications :
Flow Cytometry
Species :
Clone :
Gene Identification :
Entrez: 3690; Uniprot: P05106
Isotype :
Storage :
4° C
Description :
Integrin beta3, also known as CD61, is a 130 kDa transmembrane glycoprotein that binds noncovalently in complexes with integrin alpha subunits to form the functional receptor that binds to specific extracellular matrix proteins (e.g., fibronectin, vitronectin, etc.). Integrin receptors are involved in the regulation of a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. The clustering of integrin receptors on the cell surface and their binding to the extracellular matrix leads to the formation of focal contacts and the activation of various signal transduction pathways. Phosphorylation of tyrosine 773 on Integrin beta3 activates the receptor and promotes cell adhesion. Tyr773 is commonly referred to as Tyr747, the corresponding site in the chicken Integrin beta3 protein.
Immunogen :
White blood cells.
Format :
Liquid; PBS with 0.2 % carrier protein, 0.08 % sodium azide
Applications w/Dilutions :
FACS Assay Dependent
Aliases :
Integrin beta-3, GP3A, HPA 1, HPA 4, ITGB3, NAIT , Platelet fibrinogen receptor beta subunit, platelet glycoprotein IIIa precursor, PTP
company information
Thermo Scientific Pierce Products
PO Box 117
Rockford, IL 61105
headquarters: USA