product summary
request information :
company name :
Thermo Scientific Pierce Products
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, HyClone, ABgene, Open Biosystems, Dharmacon Research, Affinity BioReagents, Nunc
product type :
antibody
product name :
Integrin beta-3
catalog :
MA1-12149
quantity :
100 Tests
price :
246.00 USD
clonality :
monoclonal
host :
mouse
reactivity :
human
application :
FACS
more info or order :
product information
Catalog Number :
MA1-12149
product name :
Integrin beta-3
Long Product Name :
Integrin beta-3 Antibody, PE conjugate (43.PL)
product type :
antibody
List Price :
246.00 USD
clonality :
monoclonal
Host Name :
mouse
Clone :
43.PL
conjugate :
PE
Isotype :
IgG1
Product Description :
MA1-12149 detects CD61 in human samples. MA1-12149 has been successfully used in FACS procedures. The MA1-12149 immunogen is white blood cells.
CrossReactivity :
Hu
SpeciesSummary :
human
Background :
Integrin beta3, also known as CD61, is a 130 kDa transmembrane glycoprotein that binds noncovalently in complexes with integrin alpha subunits to form the functional receptor that binds to specific extracellular matrix proteins (e.g., fibronectin, vitronectin, etc.). Integrin receptors are involved in the regulation of a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. The clustering of integrin receptors on the cell surface and their binding to the extracellular matrix leads to the formation of focal contacts and the activation of various signal transduction pathways. Phosphorylation of tyrosine 773 on Integrin beta3 activates the receptor and promotes cell adhesion. Tyr773 is commonly referred to as Tyr747, the corresponding site in the chicken Integrin beta3 protein.
ALTnames :
Integrin beta-3, GP3A, HPA 1, HPA 4, ITGB3, NAIT , Platelet fibrinogen receptor beta subunit, platelet glycoprotein IIIa precursor, PTP
Immunogen :
White blood cells.
buffer :
100 tests in PBS with 0.08% sodium azide and 0.2% carrier protein.
Preservative :
0.08% Sodium azide
Packaging :
100 Tests
PackageSize :
100
Uses :
FACS (Assay Dependent)
Application Summary :
FACS
Storage :
4° C
more info or order :
company information
Thermo Scientific Pierce Products