This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
INSR Polyclonal Antibody
catalog :
PA5-14687
quantity :
400µL
price :
US 330.00
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, immunohistochemistry
product information
Product Type :
Antibody
Product Name :
INSR Polyclonal Antibody
Catalog # :
PA5-14687
Quantity :
400µL
Price :
US 330.00
Clonality :
Polyclonal
Purity :
Ammonium sulfate precipitation, Size-exclusion - Dialysis
Host :
Rabbit
Reactivity :
Human
Applications :
Immunohistochemistry: 1:50-1:100, Western Blot: 1:1000
Species :
Human
Isotype :
IgG
Storage :
-20° C, Avoid Freeze/Thaw Cycles
Description :
INSR (insulin receptor, IR) is a heterodimeric protein complex that has an intracellular beta subunit and an extracellular alpha subunit, which is disulfide- linked to a transmembrane segment. The insulin ligand binds to the IR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to IR induces phosphorylation of intracellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. INSR and IGF-1 receptors share major structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine in INSR. In humans, the INSR gene is located on chromosome 19. Defects in INSR are the cause of various insulin resistance syndromes and IGF-1R defects may also cause some forms of growth retardation.
Immunogen :
KLH conjugated synthetic peptide between 21-52 amino acids from the N-terminal region of human INSR(Insulin Receptor)
Format :
Liquid
Applications w/Dilutions :
Immunohistochemistry: 1:50-1:100, Western Blot: 1:1000
Aliases :
CD220, HHF5, IR
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA