PSEN2 Polyclonal Antibody | Invitrogen PA1-1753 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PSEN2 Polyclonal Antibody

catalog :

PA1-1753

quantity :

100 µg

price :

US 399.00

clonality :

polyclonal

host :

chicken

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

product information

Product Type :

Antibody

Product Name :

PSEN2 Polyclonal Antibody

Catalog # :

PA1-1753

Quantity :

100 µg

Price :

US 399.00

Clonality :

Polyclonal

Purity :

PEG precipitation

Host :

Chicken

Reactivity :

Human, Mouse, Rat

Applications :

Western Blot: 1 µg/mL

Species :

Human, Mouse, Rat

Isotype :

IgY

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.

Immunogen :

Mixture of synthetic peptides corresponding to residues Y(319) D P E N E E D S Y D S(330) and G(349) E E L E E E E E R G V(360) of human PS2.

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1 µg/mL

Aliases :

AD3L; AD3LP; AD4; Ad4h; AD5; Alg3; ALG-3; Alzheimer disease 4; CMD1V; E5-1; presenilin 2; presenilin-2; Presenilin-2 CTF subunit; Presenilin-2 NTF subunit; PS2; Ps-2; PSEN 2; PSEN2; Psnl2; STM2; STM-2