Phospho-Integrin beta-1 pSer785 Polyclonal Antibody | Invitrogen OPA1-03177 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon

product type :

antibody

product name :

Phospho-Integrin beta-1 pSer785 Polyclonal Antibody

catalog :

OPA1-03177

quantity :

100 µl

price :

US 349

clonality :

polyclonal

host :

rabbit

antigen modification :

phosphorylated

reactivity :

mouse, rat, chicken

application :

western blot, immunohistochemistry

citations: 1

immunohistochemistry; mouse

Hu J, Lu J, Lian G, Zhang J, Hecht J, Sheen V. Filamin B regulates chondrocyte proliferation and differentiation through Cdk1 signaling. PLoS ONE. 2014;9:e89352 pubmed publisher

product information

Product Type :

OPA1-03177

Product Name :

Phospho-Integrin beta-1 pSer785 Polyclonal Antibody

Catalog # :

OPA1-03177

Quantity :

100 µl

Price :

US 349

Clonality :

Polyclonal

Purity :

purified

Host :

Rabbit

Reactivity :

Chicken, Mouse, Rat

Applications :

Western Blot

Species :

Ck, Ms, Rt

Gene Identification :

Entrez: 374058, 16412, 24511; Uniprot: P09055, P49134

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

Integrin alpha4 (also called CD49d) is a ~130 kDa protein that possesses a large extracellular domain involved in ligand binding, a single transmembrane domain, and an intracellular regulatory domain possessing multiple sites for phosphorylation. Integrin alpha4 forms heterodimers with integrins beta1 and beta7. Integrin alpha4 is expressed on leukocytes and leukocyte precursors, neural crest cells, and developing skeletal muscles and is essential for embryogenesis, hematopoiesis, and immune responses. The presence of integrin alpha4 promotes cell migration and inhibits cell spreading and contractility. Integrin alpha4 function has been implicated in the pathogenesis of multiple diseases including asthma, rheumatoid arthritis, Crohn’s disease, ulcerative colitis, hepatitis C, and multiple sclerosis, and therefore, modulation of integrin alpha4 function has become an important target for drug discovery. Phosphorylation of the serine 988 residue on the integrin alpha4 cytoplasmic tail inhibits its interaction with the focal adhesion complex-associated protein paxillin, and modulates its effects on cell motility and spreading.

Immunogen :

Synthetic phosphopeptide derived from a region of human integrin beta1 that contains serine 785.

Format :

Liquid; Dulbecco's PBS, 1 mg/ml BSA, 50 % glycerol, 0.05 % sodium azide

Applications w/Dilutions :

WB 1:1,000

Aliases :

CD29, Fibrinogen Receptor beta subunit, GPIIA, ITGB1 , MDF2