This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
StressMarq Biosciences
product type :
chemical
product name :
Thalidomide
catalog :
SIH-336-500MG
quantity :
500 mg
price :
273.00 USD
product information
Catalog Number :
SIH-336-500MG
Item Name :
Thalidomide
Price :
273.00 USD
Research Area :
Apoptosis
Alternative Name :
(±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione, N-(2,6-dioxo-3-piperidinyl)phthalim­ide
Size :
500 mg
Product Type :
Inhibitor
Description :
E3 UB ligase inhibitor
CAS# :
50-35-1
Formula :
C13H10N204
Molecular weight :
258.2
Source/Host :
Synthetic
Purity :
>98%
Solubility :
Soluble in 5mg/mL DMSO
Appearance :
White Solid
Storage Temp (ºC) :
-20
Shipping Temp (ºC) :
Shipped Ambient
Safety Phrases :
Classification: Very toxic material causing immediate and serious toxic effects. Highly toxic teratogen. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H302 – Harmful if swallowed H360 – May damage fertility or the unborn child Precautionary Statements: P201 – Obtain special instructions before use. P308 + P313 – If exposed or concerned: Get medical advice/ attention.
Scientific Background :
Binds to the E3 ubiquitin ligase complex formed between CRBN, DDB1 and Cul4A inhibiting ligase activity. Inhibits TNF synthesis and FGF-induced angiogenesis. Cell permeable. Caution: Teratogenic.
References :
1.     Ito T., et al. (2010) Science. 327:1345. 2. Weglicki W.B., et al. (1993) Mol. Cell. Biochem. 129:195. 3. D’Amato R.J., et al. (1994) Proc. Natl. Acad. Sci. USA. 91:4082.
Date Added or Updated :
06/06/2012
company information
StressMarq Biosciences
PO Box 55036 CADBORO BAY
3825 Cadboro Bay Road
Victoria BC V8N 4G0
info@stressmarq.com
www.stressmarq.com
1-250-294-9065
headquarters: canada
StressMarq Biosciences Inc. is a bioreagents company producing high-quality antibodies, antibody conjugates, proteins, assay kits, and small molecules for the life sciences.
With over 17,000 products, we offer a wide range of products for scientists in cancer, neuroscience, epigenetics, cell signalling, and cellular stress research areas.
Based in Victoria, BC, with a small but dedicated group of scientists, StressMarq provides highly-validated products that are sold with our quality guarantee, and supported by our years of scientific expertise. Our products are available in over 50 countries through our extensive distributor network.
StressMarq draws on scientific excellence from around the globe. We strive to partner with academic or for-profit institutions through licensing agreements to bring cutting-edge research tools to the scientific community.