product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
GSK-3alpha/beta (0011-A) Antibody
catalog :
sc-7291
quantity :
200 µg/ml
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
0011-A
reactivity :
Chlamydomonas reinhardtii, human, mouse, rat, dogs, bovine
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, reverse phase protein lysate microarray, other
citations: 59
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 7e
Jacques S, Arjomand A, Per xe9 e H, Collins P, Mayer A, Lavergne A, et al. Dual-specificity phosphatase 3 deletion promotes obesity, non-alcoholic steatohepatitis and hepatocellular carcinoma. Sci Rep. 2021;11:5817 pubmed publisher
  • western blot; bovine; 1:2000; loading ...; fig 3a
Du X, He W, He H, Wang H. Beta-catenin inhibits bovine parainfluenza virus type 3 replication via innate immunity pathway. BMC Vet Res. 2020;16:72 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 7c
Gao C, Chen G, Zhang D, Zhang J, Kuan S, Hu W, et al. PYK2 Is Involved in Premalignant Acinar Cell Reprogramming and Pancreatic Ductal Adenocarcinoma Maintenance by Phosphorylating β-CateninY654. Cell Mol Gastroenterol Hepatol. 2019;8:561-578 pubmed publisher
  • other; human; loading ...; fig 4c
Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher
  • reverse phase protein lysate microarray; human; loading ...; fig st6
Cherniack A, Shen H, Walter V, Stewart C, Murray B, Bowlby R, et al. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017;31:411-423 pubmed publisher
  • reverse phase protein lysate microarray; human; loading ...; fig 3a
. Integrated genomic and molecular characterization of cervical cancer. Nature. 2017;543:378-384 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 3b
Granato M, Rizzello C, Gilardini Montani M, Cuomo L, Vitillo M, Santarelli R, et al. Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways. J Nutr Biochem. 2017;41:124-136 pubmed publisher
  • western blot; human; loading ...
Hill S, Nesser N, Johnson Camacho K, Jeffress M, Johnson A, Boniface C, et al. Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling. Cell Syst. 2017;4:73-83.e10 pubmed publisher
  • western blot; human; 1:200; fig 8e
Lin K, Kao S, Lai C, Chen C, Wu C, Hsu H, et al. Tumor Suppressor Lzap Suppresses Wnt/β-Catenin Signaling to Promote Zebrafish Embryonic Ventral Cell Fates via the Suppression of Inhibitory Phosphorylation of Glycogen Synthase Kinase 3. J Biol Chem. 2015;290:29808-19 pubmed publisher
  • immunocytochemistry; Chlamydomonas reinhardtii; 1:100; fig 5
  • ELISA; Chlamydomonas reinhardtii; 1:500; fig 5
  • western blot; Chlamydomonas reinhardtii; 1:500; fig 5
Kong J, Hardin K, Dinkins M, Wang G, He Q, Mujadzic T, et al. Regulation of Chlamydomonas flagella and ependymal cell motile cilia by ceramide-mediated translocation of GSK3. Mol Biol Cell. 2015;26:4451-65 pubmed publisher
  • western blot; mouse; 1:1000
Seo M, Lee C, Cho H, You Y, Lee B, Lee J, et al. Effects of antipsychotic drugs on the expression of synapse-associated proteins in the frontal cortex of rats subjected to immobilization stress. Psychiatry Res. 2015;229:968-74 pubmed publisher
  • western blot; human; fig 2
Morra F, Luise C, Merolla F, Poser I, Visconti R, Ilardi G, et al. FBXW7 and USP7 regulate CCDC6 turnover during the cell cycle and affect cancer drugs susceptibility in NSCLC. Oncotarget. 2015;6:12697-709 pubmed
  • western blot; human
Giovannini C, Minguzzi M, Baglioni M, Fornari F, Giannone F, Ravaioli M, et al. Suppression of p53 by Notch3 is mediated by Cyclin G1 and sustained by MDM2 and miR-221 axis in hepatocellular carcinoma. Oncotarget. 2014;5:10607-20 pubmed
  • western blot; mouse
Young M, Brewer R, Peliciari Garcia R, Collins H, He L, Birky T, et al. Cardiomyocyte-specific BMAL1 plays critical roles in metabolism, signaling, and maintenance of contractile function of the heart. J Biol Rhythms. 2014;29:257-76 pubmed publisher
  • western blot; mouse; fig 2a
Chu Y, Gómez Rosso L, Huang P, Wang Z, Xu Y, Yao X, et al. Liver Med23 ablation improves glucose and lipid metabolism through modulating FOXO1 activity. Cell Res. 2014;24:1250-65 pubmed publisher
  • western blot; human
Xu L, Long Z, Peng F, Liu Y, Xu J, Wang C, et al. Aurora kinase a suppresses metabolic stress-induced autophagic cell death by activating mTOR signaling in breast cancer cells. Oncotarget. 2014;5:7498-511 pubmed
  • western blot; human
Izumi H, Kaneko Y. Trim32 facilitates degradation of MYCN on spindle poles and induces asymmetric cell division in human neuroblastoma cells. Cancer Res. 2014;74:5620-30 pubmed publisher
  • western blot; human; fig 5
Azzolin L, Panciera T, Soligo S, Enzo E, Bicciato S, Dupont S, et al. YAP/TAZ incorporation in the ?-catenin destruction complex orchestrates the Wnt response. Cell. 2014;158:157-70 pubmed publisher
Sharma V, Joshi J, Yeh I, Doughman Y, Blankenberg D, Wald D, et al. Re-Expression of ERα and AR in Receptor Negative Endocrine Cancers via GSK3 Inhibition. Front Oncol. 2022;12:824594 pubmed publisher
Zhang H, Lin M, Dong C, Tang Y, An L, Ju J, et al. An MST4-pβ-CateninThr40 Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis. Adv Sci (Weinh). 2021;8:e2004850 pubmed publisher
Chang Y, Tam H, Lu M, Huang H. Gemcitabine-induced Gli-dependent activation of hedgehog pathway resists to the treatment of urothelial carcinoma cells. PLoS ONE. 2021;16:e0254011 pubmed publisher
Yang Y, Chan W. Glycogen Synthase Kinase 3 Beta Regulates the Human Aryl Hydrocarbon Receptor Cellular Content and Activity. Int J Mol Sci. 2021;22: pubmed publisher
Zhu R, Li L, Nguyen B, Seo J, Wu M, Seale T, et al. FLT3 tyrosine kinase inhibitors synergize with BCL-2 inhibition to eliminate FLT3/ITD acute leukemia cells through BIM activation. Signal Transduct Target Ther. 2021;6:186 pubmed publisher
Kim J, Yang J, Kim E. SIRT1 and AROS suppress doxorubicin-induced apoptosis via inhibition of GSK3β activity in neuroblastoma cells. Anim Cells Syst (Seoul). 2020;24:53-59 pubmed publisher
Adhikari A, Davie J. JARID2 and the PRC2 complex regulate skeletal muscle differentiation through regulation of canonical Wnt signaling. Epigenetics Chromatin. 2018;11:46 pubmed publisher
de Blas E, Estañ M, Del Carmen Gómez de Frutos M, Ramos J, Del Carmen Boyano Adánez M, Aller P. Selected polyphenols potentiate the apoptotic efficacy of glycolytic inhibitors in human acute myeloid leukemia cell lines. Regulation by protein kinase activities. Cancer Cell Int. 2016;16:70 pubmed publisher
Lu H, Gao Z, Zhao Z, Weng J, Ye J. Transient hypoxia reprograms differentiating adipocytes for enhanced insulin sensitivity and triglyceride accumulation. Int J Obes (Lond). 2016;40:121-8 pubmed publisher
Xu R, Hu Q, Ma Q, Liu C, Wang G. The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway. Cell Death Dis. 2014;5:e1373 pubmed publisher
Nicot A, Lo Verso F, Ratti F, Pilot Storck F, Streichenberger N, Sandri M, et al. Phosphorylation of NBR1 by GSK3 modulates protein aggregation. Autophagy. 2014;10:1036-53 pubmed publisher
Alfaradhi M, Fernandez Twinn D, Martin Gronert M, Musial B, Fowden A, Ozanne S. Oxidative stress and altered lipid homeostasis in the programming of offspring fatty liver by maternal obesity. Am J Physiol Regul Integr Comp Physiol. 2014;307:R26-34 pubmed publisher
Giovannini C, Baglioni M, Baron Toaldo M, Ventrucci C, D Adamo S, Cipone M, et al. Notch3 inhibition enhances sorafenib cytotoxic efficacy by promoting GSK3b phosphorylation and p21 down-regulation in hepatocellular carcinoma. Oncotarget. 2013;4:1618-31 pubmed
Nicastro H, Firestone G, Bjeldanes L. 3,3'-diindolylmethane rapidly and selectively inhibits hepatocyte growth factor/c-Met signaling in breast cancer cells. J Nutr Biochem. 2013;24:1882-8 pubmed publisher
Li H, Jeong H, Choi Y, Lee S, Jeong H, Jeong T, et al. Glycogen synthase kinase 3 alpha phosphorylates and regulates the osteogenic activity of Osterix. Biochem Biophys Res Commun. 2013;434:653-8 pubmed publisher
Zurashvili T, Cordón Barris L, Ruiz Babot G, Zhou X, Lizcano J, Gómez N, et al. Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation but dispensable for neuronal survival. Mol Cell Biol. 2013;33:1027-40 pubmed publisher
Barrell W, Szabo Rogers H, Liu K. Novel reporter alleles of GSK-3? and GSK-3?. PLoS ONE. 2012;7:e50422 pubmed publisher
Kim S, Yang D, Myeong J, Ha K, Kim S, Park E, et al. Regulation of calcium influx and signaling pathway in cancer cells via TRPV6-Numb1 interaction. Cell Calcium. 2013;53:102-11 pubmed publisher
Pouladi M, Brillaud E, Xie Y, Conforti P, Graham R, Ehrnhoefer D, et al. NP03, a novel low-dose lithium formulation, is neuroprotective in the YAC128 mouse model of Huntington disease. Neurobiol Dis. 2012;48:282-9 pubmed publisher
Haines C, Harvey P, Leinwand L. Estrogens mediate cardiac hypertrophy in a stimulus-dependent manner. Endocrinology. 2012;153:4480-90 pubmed publisher
Byun H, Jung H, Seo Y, Lee Y, Hwang S, Hwang E, et al. GSK3 inactivation is involved in mitochondrial complex IV defect in transforming growth factor (TGF) ?1-induced senescence. Exp Cell Res. 2012;318:1808-19 pubmed publisher
Hung S, Chiang H, Wu C, Hsu M, Chen Y. Effects of herpes simplex virus type 1 infection on immune functions of human neutrophils. J Periodontal Res. 2012;47:635-44 pubmed publisher
Dieni C, Bouffard M, Storey K. Glycogen synthase kinase-3: cryoprotection and glycogen metabolism in the freeze-tolerant wood frog. J Exp Biol. 2012;215:543-51 pubmed publisher
Gutierrez A, Snyder E, Mariño Enríquez A, Zhang Y, Sioletic S, Kozakewich E, et al. Aberrant AKT activation drives well-differentiated liposarcoma. Proc Natl Acad Sci U S A. 2011;108:16386-91 pubmed publisher
Kivimäe S, Yang X, Cheyette B. All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases. BMC Biochem. 2011;12:33 pubmed publisher
Hennessy B, Lu Y, Gonzalez Angulo A, Carey M, Myhre S, Ju Z, et al. A Technical Assessment of the Utility of Reverse Phase Protein Arrays for the Study of the Functional Proteome in Non-microdissected Human Breast Cancers. Clin Proteomics. 2010;6:129-51 pubmed publisher
Riadh N, Allagui M, Bourogaa E, Vincent C, Croute F, Elfeki A. Neuroprotective and neurotrophic effects of long term lithium treatment in mouse brain. Biometals. 2011;24:747-57 pubmed publisher
He Q, Gao Z, Yin J, Zhang J, Yun Z, Ye J. Regulation of HIF-1{alpha} activity in adipose tissue by obesity-associated factors: adipogenesis, insulin, and hypoxia. Am J Physiol Endocrinol Metab. 2011;300:E877-85 pubmed publisher
Honda T, Yamamoto H, Ishii A, Inui M. PDZRN3 negatively regulates BMP-2-induced osteoblast differentiation through inhibition of Wnt signaling. Mol Biol Cell. 2010;21:3269-77 pubmed publisher
Giliberto L, d Abramo C, Acker C, Davies P, D ADAMIO L. Transgenic expression of the amyloid-beta precursor protein-intracellular domain does not induce Alzheimer's Disease-like traits in vivo. PLoS ONE. 2010;5:e11609 pubmed publisher
Ho W, Lee Y, Chang L, Chen Y, Liu T, Hung S. Effects of areca nut extract on the apoptosis pathways in human neutrophils. J Periodontal Res. 2010;45:412-20 pubmed publisher
Ahmed S, Milner J. Basal cancer cell survival involves JNK2 suppression of a novel JNK1/c-Jun/Bcl-3 apoptotic network. PLoS ONE. 2009;4:e7305 pubmed publisher
Yin J, Zuberi A, Gao Z, Liu D, Liu Z, Ye J. Shilianhua extract inhibits GSK-3beta and promotes glucose metabolism. Am J Physiol Endocrinol Metab. 2009;296:E1275-80 pubmed publisher
Seo Y, Jung H, Shin H, Kim Y, Yim H, Chung H, et al. Enhanced glycogenesis is involved in cellular senescence via GSK3/GS modulation. Aging Cell. 2008;7:894-907 pubmed publisher
Lee H, Tsai J, Liao P, Tsai W, Lin K, Chuang C, et al. Glycogen synthase kinase 3 alpha and 3 beta have distinct functions during cardiogenesis of zebrafish embryo. BMC Dev Biol. 2007;7:93 pubmed
Rider V, Isuzugawa K, Twarog M, Jones S, Cameron B, Imakawa K, et al. Progesterone initiates Wnt-beta-catenin signaling but estradiol is required for nuclear activation and synchronous proliferation of rat uterine stromal cells. J Endocrinol. 2006;191:537-48 pubmed
Krishnamurthy K, Wang G, Silva J, Condie B, Bieberich E. Ceramide regulates atypical PKCzeta/lambda-mediated cell polarity in primitive ectoderm cells. A novel function of sphingolipids in morphogenesis. J Biol Chem. 2007;282:3379-90 pubmed
Koivisto L, Jiang G, Hakkinen L, Chan B, Larjava H. HaCaT keratinocyte migration is dependent on epidermal growth factor receptor signaling and glycogen synthase kinase-3alpha. Exp Cell Res. 2006;312:2791-805 pubmed
Hébert S, Serneels L, Tolia A, Craessaerts K, Derks C, Filippov M, et al. Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes. EMBO Rep. 2006;7:739-45 pubmed
Morgan Lappe S, Woods K, Li Q, Anderson M, Schurdak M, Luo Y, et al. RNAi-based screening of the human kinome identifies Akt-cooperating kinases: a new approach to designing efficacious multitargeted kinase inhibitors. Oncogene. 2006;25:1340-8 pubmed
Tang X, Powelka A, Soriano N, Czech M, Guilherme A. PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes. J Biol Chem. 2005;280:22523-9 pubmed
product information
Product Name :
GSK-3alpha/beta (0011-A) Antibody
Gene Name :
GSK3A, GSK3B
Size :
200 µg/ml
Catalog Number :
sc-7291
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
GSK-3alpha/beta
reactive species  :
m, r, h, canine, Xenopus
Application :
WB, IP, IF, IHC(P), FCM
Epitope :
1-420 ( X )
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA