product summary
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company name :
R and D Systems
product type :
product name :
Human IL-6 DuoSet
catalog :
quantity :
1 Kit
price :
645 USD
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citations: 84
Published Application/Species/DilutionReference
  • ELISA; human
Young O, Tang Z, Niven-Fairchild T, Tadesse S, Krikun G, Norwitz E, et al. Toll-like receptor-mediated responses by placental Hofbauer cells (HBCs): a potential pro-inflammatory role for fetal M2 macrophages. Am J Reprod Immunol. 2015;73:22-35 pubmed publisher
  • ELISA; human
Moliva J, Rajaram M, Sidiki S, Sasindran S, Guirado E, Pan X, et al. Molecular composition of the alveolar lining fluid in the aging lung. Age (Dordr). 2014;36:9633 pubmed publisher
Perry M, Tsitsiou E, Austin P, Lindsay M, Gibeon D, Adcock I, et al. Role of non-coding RNAs in maintaining primary airway smooth muscle cells. Respir Res. 2014;15:58 pubmed publisher
Xiang Q, Chen L, Hou S, Fang J, Zhou Y, Bai L, et al. TRAF5 and TRAF3IP2 gene polymorphisms are associated with Behçet's disease and Vogt-Koyanagi-Harada syndrome: a case-control study. PLoS ONE. 2014;9:e84214 pubmed publisher
Dreymueller D, Martin C, Schumacher J, Groth E, Boehm J, Reiss L, et al. Smooth muscle cells relay acute pulmonary inflammation via distinct ADAM17/ErbB axes. J Immunol. 2014;192:722-31 pubmed publisher
Jeffery H, Soderberg-Naucler C, Butler L. Human cytomegalovirus induces a biphasic inflammatory response in primary endothelial cells. J Virol. 2013;87:6530-5 pubmed publisher
Parola C, Salogni L, Vaira X, Scutera S, Somma P, Salvi V, et al. Selective activation of human dendritic cells by OM-85 through a NF-kB and MAPK dependent pathway. PLoS ONE. 2013;8:e82867 pubmed publisher
Wallace A, Host A, Whitley G, Cartwright J. Decidual natural killer cell interactions with trophoblasts are impaired in pregnancies at increased risk of preeclampsia. Am J Pathol. 2013;183:1853-61 pubmed publisher
Alvarez J, Zughaier S, Law J, Hao L, Wasse H, Ziegler T, et al. Effects of high-dose cholecalciferol on serum markers of inflammation and immunity in patients with early chronic kidney disease. Eur J Clin Nutr. 2013;67:264-9 pubmed publisher
Boyd A, Bennuru S, Wang Y, Sanprasert V, Law M, Chaussabel D, et al. Quiescent innate response to infective filariae by human Langerhans cells suggests a strategy of immune evasion. Infect Immun. 2013;81:1420-9 pubmed publisher
Punsmann S, Liebers V, Lotz A, Bruning T, Raulf M. Ex vivo cytokine release and pattern recognition receptor expression of subjects exposed to dampness: pilot study to assess the outcome of mould exposure to the innate immune system. PLoS ONE. 2013;8:e82734 pubmed publisher
Karadag A, Zhou M, Croucher P. ADAM-9 (MDC-9/meltrin-gamma), a member of the a disintegrin and metalloproteinase family, regulates myeloma-cell-induced interleukin-6 production in osteoblasts by direct interaction with the alpha(v)beta5 integrin. Blood. 2006;107:3271-8 pubmed
Aliahmadi E, Gramlich R, Grützkau A, Hitzler M, Krüger M, Baumgrass R, et al. TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23. Eur J Immunol. 2009;39:1221-30 pubmed publisher
Bellini A, Marini M, Bianchetti L, Barczyk M, Schmidt M, Mattoli S. Interleukin (IL)-4, IL-13, and IL-17A differentially affect the profibrotic and proinflammatory functions of fibrocytes from asthmatic patients. Mucosal Immunol. 2012;5:140-9 pubmed publisher
Luo D, Fielding C, Phillips A, Fraser D. Interleukin-1 beta regulates proximal tubular cell transforming growth factor beta-1 signalling. Nephrol Dial Transplant. 2009;24:2655-65 pubmed publisher
Gaskill P, Carvallo L, Eugenin E, Berman J. Characterization and function of the human macrophage dopaminergic system: implications for CNS disease and drug abuse. J Neuroinflammation. 2012;9:203 pubmed publisher
Macagno A, Molteni M, Rinaldi A, Bertoni F, Lanzavecchia A, Rossetti C, et al. A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression. J Exp Med. 2006;203:1481-92 pubmed
Novitskiy S, Ryzhov S, Zaynagetdinov R, Goldstein A, Huang Y, Tikhomirov O, et al. Adenosine receptors in regulation of dendritic cell differentiation and function. Blood. 2008;112:1822-31 pubmed publisher
LeBouder E, Rey-Nores J, Raby A, Affolter M, Vidal K, Thornton C, et al. Modulation of neonatal microbial recognition: TLR-mediated innate immune responses are specifically and differentially modulated by human milk. J Immunol. 2006;176:3742-52 pubmed
Arndts K, Deininger S, Specht S, Klarmann U, Mand S, Adjobimey T, et al. Elevated adaptive immune responses are associated with latent infections of Wuchereria bancrofti. PLoS Negl Trop Dis. 2012;6:e1611 pubmed publisher
Niemeyer C, Adler M, Wacker R. Detecting antigens by quantitative immuno-PCR. Nat Protoc. 2007;2:1918-30 pubmed
Hawn T, Scholes D, Wang H, Li S, Stapleton A, Janer M, et al. Genetic variation of the human urinary tract innate immune response and asymptomatic bacteriuria in women. PLoS ONE. 2009;4:e8300 pubmed publisher
Breitkreutz I, Raab M, Vallet S, Hideshima T, Raje N, Chauhan D, et al. Targeting MEK1/2 blocks osteoclast differentiation, function and cytokine secretion in multiple myeloma. Br J Haematol. 2007;139:55-63 pubmed
Eikawa S, Ohue Y, Kitaoka K, Aji T, Uenaka A, Oka M, et al. Enrichment of Foxp3+ CD4 regulatory T cells in migrated T cells to IL-6- and IL-8-expressing tumors through predominant induction of CXCR1 by IL-6. J Immunol. 2010;185:6734-40 pubmed publisher
Christophi G, Panos M, Hudson C, Tsikkou C, Mihai C, Mejico L, et al. Interferon-beta treatment in multiple sclerosis attenuates inflammatory gene expression through inducible activity of the phosphatase SHP-1. Clin Immunol. 2009;133:27-44 pubmed publisher
Kjellerup R, Kragballe K, Iversen L, Johansen C. Pro-inflammatory cytokine release in keratinocytes is mediated through the MAPK signal-integrating kinases. Exp Dermatol. 2008;17:498-504 pubmed
Fusshoeller A, Plail M, Grabensee B, Plum J. Biocompatibility pattern of a bicarbonate/lactate-buffered peritoneal dialysis fluid in APD: a prospective, randomized study. Nephrol Dial Transplant. 2004;19:2101-6 pubmed
Peake N, Khawaja K, Myers A, Nowell M, Jones S, Rowan A, et al. Interleukin-6 signalling in juvenile idiopathic arthritis is limited by proteolytically cleaved soluble interleukin-6 receptor. Rheumatology (Oxford). 2006;45:1485-9 pubmed
Scutera S, Fraone T, Musso T, Cappello P, Rossi S, Pierobon D, et al. Survival and migration of human dendritic cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway. J Immunol. 2009;183:3004-13 pubmed publisher
Zhao S, Gu Y, Dong Q, Fan R, Wang Y. Altered interleukin-6 receptor, IL-6R and gp130, production and expression and decreased SOCS-3 expression in placentas from women with pre-eclampsia. Placenta. 2008;29:1024-8 pubmed publisher
Knobloch J, Hag H, Jungck D, Urban K, Koch A. Resveratrol impairs the release of steroid-resistant cytokines from bacterial endotoxin-exposed alveolar macrophages in chronic obstructive pulmonary disease. Basic Clin Pharmacol Toxicol. 2011;109:138-43 pubmed publisher
Gokhale R, Chandrashekara S, Vasanthakumar K. Cytokine response to strenuous exercise in athletes and non-athletes--an adaptive response. Cytokine. 2007;40:123-7 pubmed
Kallio R, Sequeiros R, Surcel H, Ohtonen P, Kiviniemi H, Syrjala H. Early cytokine responses after percutaneous magnetic resonance imaging guided laser thermoablation of malignant liver tumors. Cytokine. 2006;34:278-83 pubmed
Birrell M, Wong S, Dekkak A, De Alba J, Haj-Yahia S, Belvisi M. Role of matrix metalloproteinases in the inflammatory response in human airway cell-based assays and in rodent models of airway disease. J Pharmacol Exp Ther. 2006;318:741-50 pubmed
Correale J, Farez M, Razzitte G. Helminth infections associated with multiple sclerosis induce regulatory B cells. Ann Neurol. 2008;64:187-99 pubmed publisher
Cheong Y, Shelton J, Laird S, Richmond M, Kudesia G, Li T, et al. IL-1, IL-6 and TNF-alpha concentrations in the peritoneal fluid of women with pelvic adhesions. Hum Reprod. 2002;17:69-75 pubmed
Wilhelmsen K, Mesa K, Prakash A, Xu F, Hellman J. Activation of endothelial TLR2 by bacterial lipoprotein upregulates proteins specific for the neutrophil response. Innate Immun. 2012;18:602-16 pubmed publisher
Ahmed S, Marotte H, Kwan K, Ruth J, Campbell P, Rabquer B, et al. Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses transsignaling by enhancing soluble gp130 production. Proc Natl Acad Sci U S A. 2008;105:14692-7 pubmed publisher
Lignell U, Meklin T, Putus T, Vepsäläinen A, Roponen M, Torvinen E, et al. Microbial exposure, symptoms and inflammatory mediators in nasal lavage fluid of kitchen and clerical personnel in schools. Int J Occup Med Environ Health. 2005;18:139-50 pubmed
Hung M, Cherng W, Cheng C, Li L. Comparison of serum levels of inflammatory markers in patients with coronary vasospasm without significant fixed coronary artery disease versus patients with stable angina pectoris and acute coronary syndromes with significant fixed coronary artery diseas. Am J Cardiol. 2006;97:1429-34 pubmed
Bender L, Thaarup J, Varming K, Krarup H, Ellermann-Eriksen S, Ebbesen F. Early and late markers for the detection of early-onset neonatal sepsis. Dan Med Bull. 2008;55:219-23 pubmed
Birrell M, Wong S, Catley M, Belvisi M. Impact of tobacco-smoke on key signaling pathways in the innate immune response in lung macrophages. J Cell Physiol. 2008;214:27-37 pubmed
Roponen M, Kiviranta J, Seuri M, Tukiainen H, Hirvonen M. Inflammatory mediators in nasal lavage, induced sputum and serum of employees with rheumatic and respiratory disorders. Eur Respir J. 2001;18:542-8 pubmed
Suh H, Choi N, Tarassishin L, Lee S. Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12). PLoS ONE. 2012;7:e35115 pubmed publisher
Aydin S, Signorelli S, Lechleitner T, Joannidis M, Pleban C, Perco P, et al. Influence of microvascular endothelial cells on transcriptional regulation of proximal tubular epithelial cells. Am J Physiol Cell Physiol. 2008;294:C543-54 pubmed
Zhang J, Shan L, Koussih L, Redhu N, Halayko A, Chakir J, et al. Pentraxin 3 (PTX3) expression in allergic asthmatic airways: role in airway smooth muscle migration and chemokine production. PLoS ONE. 2012;7:e34965 pubmed publisher
Abolhassani M, Guais A, Chaumet-Riffaud P, Sasco A, Schwartz L. Carbon dioxide inhalation causes pulmonary inflammation. Am J Physiol Lung Cell Mol Physiol. 2009;296:L657-65 pubmed publisher
Khankin E, Mutter W, Tamez H, Yuan H, Karumanchi S, Thadhani R. Soluble erythropoietin receptor contributes to erythropoietin resistance in end-stage renal disease. PLoS ONE. 2010;5:e9246 pubmed publisher
Fritz J, Girardin S, Fitting C, Werts C, Mengin-Lecreulx D, Caroff M, et al. Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists. Eur J Immunol. 2005;35:2459-70 pubmed
Gupta S, Aranha C, Mohanty M, Reddy K. Toll-like receptors and cytokines as surrogate biomarkers for evaluating vaginal immune response following microbicide administration. Mediators Inflamm. 2008;2008:534532 pubmed publisher
Ishitsuka K, Hideshima T, Neri P, Vallet S, Shiraishi N, Okawa Y, et al. p38 mitogen-activated protein kinase inhibitor LY2228820 enhances bortezomib-induced cytotoxicity and inhibits osteoclastogenesis in multiple myeloma; therapeutic implications. Br J Haematol. 2008;141:598-606 pubmed publisher
Ikeda H, Hideshima T, Fulciniti M, Perrone G, Miura N, Yasui H, et al. PI3K/p110{delta} is a novel therapeutic target in multiple myeloma. Blood. 2010;116:1460-8 pubmed publisher
Berthelot L, Papista C, Maciel T, Biarnes-Pelicot M, Tissandié E, Wang P, et al. Transglutaminase is essential for IgA nephropathy development acting through IgA receptors. J Exp Med. 2012;209:793-806 pubmed publisher
Wu T, Xie C, Wang H, Zhou X, Schwartz N, Calixto S, et al. Elevated urinary VCAM-1, P-selectin, soluble TNF receptor-1, and CXC chemokine ligand 16 in multiple murine lupus strains and human lupus nephritis. J Immunol. 2007;179:7166-75 pubmed
Pennino D, Eyerich K, Scarponi C, Carbone T, Eyerich S, Nasorri F, et al. IL-17 amplifies human contact hypersensitivity by licensing hapten nonspecific Th1 cells to kill autologous keratinocytes. J Immunol. 2010;184:4880-8 pubmed publisher
Elsawa S, Almada L, Ziesmer S, Novak A, Witzig T, Ansell S, et al. GLI2 transcription factor mediates cytokine cross-talk in the tumor microenvironment. J Biol Chem. 2011;286:21524-34 pubmed publisher
Grossmann R, Zughaier S, Liu S, Lyles R, Tangpricha V. Impact of vitamin D supplementation on markers of inflammation in adults with cystic fibrosis hospitalized for a pulmonary exacerbation. Eur J Clin Nutr. 2012;66:1072-4 pubmed publisher
Salaun B, Coste I, Rissoan M, Lebecque S, Renno T. TLR3 can directly trigger apoptosis in human cancer cells. J Immunol. 2006;176:4894-901 pubmed
van de Veerdonk F, Stoeckman A, Wu G, Boeckermann A, Azam T, Netea M, et al. IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist. Proc Natl Acad Sci U S A. 2012;109:3001-5 pubmed publisher
Breitkreutz I, Raab M, Vallet S, Hideshima T, Raje N, Mitsiades C, et al. Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma. Leukemia. 2008;22:1925-32 pubmed publisher
Weigert J, Neumeier M, Wanninger J, Wurm S, Kopp A, Schober F, et al. Reduced response to adiponectin and lower abundance of adiponectin receptor proteins in type 2 diabetic monocytes. FEBS Lett. 2008;582:1777-82 pubmed publisher
Eid R, Rao D, Zhou J, Lo S, Ranjbaran H, Gallo A, et al. Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells. Circulation. 2009;119:1424-32 pubmed publisher
Jensen G, Krause C, Sotzing G, Rusling J. Inkjet-printed gold nanoparticle electrochemical arrays on plastic. Application to immunodetection of a cancer biomarker protein. Phys Chem Chem Phys. 2011;13:4888-94 pubmed publisher
Khasraw M, Pavlakis N, McCowatt S, Underhill C, Begbie S, de Souza P, et al. Multicentre phase I/II study of PI-88, a heparanase inhibitor in combination with docetaxel in patients with metastatic castrate-resistant prostate cancer. Ann Oncol. 2010;21:1302-7 pubmed publisher
Cheong Y, Laird S, Shelton J, Ledger W, Li T, Cooke I. The correlation of adhesions and peritoneal fluid cytokine concentrations: a pilot study. Hum Reprod. 2002;17:1039-45 pubmed
Palmer G, Trolliet S, Talabot-Ayer D, Mezin F, Magne D, Gabay C. Pre-interleukin-1alpha expression reduces cell growth and increases interleukin-6 production in SaOS-2 osteosarcoma cells: Differential inhibitory effect of interleukin-1 receptor antagonist (icIL-1Ra1). Cytokine. 2005;31:153-60 pubmed
Huang Q, Sobkoviak R, Jockheck-Clark A, Shi B, Mandelin A, Tak P, et al. Heat shock protein 96 is elevated in rheumatoid arthritis and activates macrophages primarily via TLR2 signaling. J Immunol. 2009;182:4965-73 pubmed publisher
Marcondes A, Li X, Tabellini L, Bartenstein M, Kabacka J, Sale G, et al. Inhibition of IL-32 activation by α-1 antitrypsin suppresses alloreactivity and increases survival in an allogeneic murine marrow transplantation model. Blood. 2011;118:5031-9 pubmed publisher
Wilhelmsen K, Mesa K, Lucero J, Xu F, Hellman J. ERK5 protein promotes, whereas MEK1 protein differentially regulates, the Toll-like receptor 2 protein-dependent activation of human endothelial cells and monocytes. J Biol Chem. 2012;287:26478-94 pubmed publisher
Damsgaard C, Lauritzen L, Calder P, Kjaer T, Frøkiaer H. Reduced ex vivo interleukin-6 production by dietary fish oil is not modified by linoleic acid intake in healthy men. J Nutr. 2009;139:1410-4 pubmed publisher
Lysaght J, van der Stok E, Allott E, Casey R, Donohoe C, Howard J, et al. Pro-inflammatory and tumour proliferative properties of excess visceral adipose tissue. Cancer Lett. 2011;312:62-72 pubmed publisher
Birrell M, Catley M, Hardaker E, Wong S, Willson T, McCluskie K, et al. Novel role for the liver X nuclear receptor in the suppression of lung inflammatory responses. J Biol Chem. 2007;282:31882-90 pubmed
Poulain-Godefroy O, Froguel P. Preadipocyte response and impairment of differentiation in an inflammatory environment. Biochem Biophys Res Commun. 2007;356:662-7 pubmed
Correale J, Farez M. Helminth antigens modulate immune responses in cells from multiple sclerosis patients through TLR2-dependent mechanisms. J Immunol. 2009;183:5999-6012 pubmed publisher
Purokivi M, Hirvonen M, Roponen M, Randell J, Vahteristo M, Tukiainen H. Comparison of inflammatory elements in nasal lavage and induced sputum following occupational exposure to moldy-building microbes. Inhal Toxicol. 2002;14:653-62 pubmed
Purokivi M, Randell J, Hirvonen M, Tukiainen H. Reproducibility of measurements of exhaled NO, and cell count and cytokine concentrations in induced sputum. Eur Respir J. 2000;16:242-6 pubmed
Lamhamedi-Cherradi S, Martin R, Ito T, Kheradmand F, CORRY D, Liu Y, et al. Fungal proteases induce Th2 polarization through limited dendritic cell maturation and reduced production of IL-12. J Immunol. 2008;180:6000-9 pubmed
Harding G, Mak Y, Evans B, Cheung J, MacDonald D, Hampson G. The effects of dexamethasone and dehydroepiandrosterone (DHEA) on cytokines and receptor expression in a human osteoblastic cell line: potential steroid-sparing role for DHEA. Cytokine. 2006;36:57-68 pubmed
Drannik A, Nag K, Yao X, Henrick B, Sallenave J, Rosenthal K. Trappin-2/elafin modulate innate immune responses of human endometrial epithelial cells to PolyI:C. PLoS ONE. 2012;7:e35866 pubmed publisher
Miranda-Carús M, Balsa A, Benito-Miguel M, Pérez de Ayala C, Martín-Mola E. IL-15 and the initiation of cell contact-dependent synovial fibroblast-T lymphocyte cross-talk in rheumatoid arthritis: effect of methotrexate. J Immunol. 2004;173:1463-76 pubmed
Somerfield J, Hill-Cawthorne G, Lin A, Zandi M, McCarthy C, Jones J, et al. A novel strategy to reduce the immunogenicity of biological therapies. J Immunol. 2010;185:763-8 pubmed publisher
Hao Q, Wang L, Tang H. Vascular endothelial growth factor induces protein kinase D-dependent production of proinflammatory cytokines in endothelial cells. Am J Physiol Cell Physiol. 2009;296:C821-7 pubmed publisher
Weindl G, Naglik J, Kaesler S, Biedermann T, Hube B, Korting H, et al. Human epithelial cells establish direct antifungal defense through TLR4-mediated signaling. J Clin Invest. 2007;117:3664-72 pubmed
Kuo H, Yang Y, Chuang J, Tiao M, Yu H, Huang L, et al. Inflammation-induced hepcidin is associated with the development of anemia and coronary artery lesions in Kawasaki disease. J Clin Immunol. 2012;32:746-52 pubmed publisher
product information
Main Category :
SubCategory :
DuoSet ELISA Development Systems
Molecule :
Species :
Catalog Number :
Long Description :
Human IL-6 DuoSet
1 Kit
Price (USD) :
645 USD
GBP (Pound Sterling) :
CHF (Swiss Franc) :
SEK (Swedish Krone) :
DKK (Danish Krone) :
NOK (Norwegian Krone) :
ELISA Range :
9.38-600 pg/mL
Protein Synonyms :
DY206, hIL-6 DuoSet, Duo Set
Keywords :
IL- 6
more info or order :
company information
R and D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
800 343-7475
headquarters: USA