product summary
request information :
company name :
R and D Systems
product type :
product name :
Human IL-6 DuoSet
catalog :
quantity :
1 Kit
price :
645 USD
publications citing this reagent :
total: 84
  1. human (ELISA)
    Young O, Tang Z, Niven-Fairchild T, Tadesse S, Krikun G, Norwitz E, et al. Toll-like receptor-mediated responses by placental Hofbauer cells (HBCs): a potential pro-inflammatory role for fetal M2 macrophages. Am J Reprod Immunol. 2015;73:22-35 pubmed publisher
  2. Perry M, Tsitsiou E, Austin P, Lindsay M, Gibeon D, Adcock I, et al. Role of non-coding RNAs in maintaining primary airway smooth muscle cells. Respir Res. 2014;15:58 pubmed publisher
  3. human (ELISA)
    Moliva J, Rajaram M, Sidiki S, Sasindran S, Guirado E, Pan X, et al. Molecular composition of the alveolar lining fluid in the aging lung. Age (Dordr). 2014;36:9633 pubmed publisher
  4. Xiang Q, Chen L, Hou S, Fang J, Zhou Y, Bai L, et al. TRAF5 and TRAF3IP2 gene polymorphisms are associated with Behçet's disease and Vogt-Koyanagi-Harada syndrome: a case-control study. PLoS ONE. 2014;9:e84214 pubmed publisher
  5. Parola C, Salogni L, Vaira X, Scutera S, Somma P, Salvi V, et al. Selective activation of human dendritic cells by OM-85 through a NF-kB and MAPK dependent pathway. PLoS ONE. 2013;8:e82867 pubmed publisher
  6. Dreymueller D, Martin C, Schumacher J, Groth E, Boehm J, Reiss L, et al. Smooth muscle cells relay acute pulmonary inflammation via distinct ADAM17/ErbB axes. J Immunol. 2014;192:722-31 pubmed publisher
  7. Punsmann S, Liebers V, Lotz A, Bruning T, Raulf M. Ex vivo cytokine release and pattern recognition receptor expression of subjects exposed to dampness: pilot study to assess the outcome of mould exposure to the innate immune system. PLoS ONE. 2013;8:e82734 pubmed publisher
  8. Wallace A, Host A, Whitley G, Cartwright J. Decidual natural killer cell interactions with trophoblasts are impaired in pregnancies at increased risk of preeclampsia. Am J Pathol. 2013;183:1853-61 pubmed publisher
  9. Jeffery H, Soderberg-Naucler C, Butler L. Human cytomegalovirus induces a biphasic inflammatory response in primary endothelial cells. J Virol. 2013;87:6530-5 pubmed publisher
  10. Boyd A, Bennuru S, Wang Y, Sanprasert V, Law M, Chaussabel D, et al. Quiescent innate response to infective filariae by human Langerhans cells suggests a strategy of immune evasion. Infect Immun. 2013;81:1420-9 pubmed publisher
more info or order :
product information
Main Category :
SubCategory :
DuoSet ELISA Development Systems
Molecule :
Species :
Catalog Number :
Long Description :
Human IL-6 DuoSet
1 Kit
Price (USD) :
645 USD
GBP (Pound Sterling) :
CHF (Swiss Franc) :
SEK (Swedish Krone) :
DKK (Danish Krone) :
NOK (Norwegian Krone) :
ELISA Range :
9.38-600 pg/mL
Protein Synonyms :
DY206, hIL-6 DuoSet, Duo Set
Keywords :
IL- 6
publications citing this reagent :
  1. Alvarez J, Zughaier S, Law J, Hao L, Wasse H, Ziegler T, et al. Effects of high-dose cholecalciferol on serum markers of inflammation and immunity in patients with early chronic kidney disease. Eur J Clin Nutr. 2013;67:264-9 pubmed publisher
  2. Gaskill P, Carvallo L, Eugenin E, Berman J. Characterization and function of the human macrophage dopaminergic system: implications for CNS disease and drug abuse. J Neuroinflammation. 2012;9:203 pubmed publisher
  3. Grossmann R, Zughaier S, Liu S, Lyles R, Tangpricha V. Impact of vitamin D supplementation on markers of inflammation in adults with cystic fibrosis hospitalized for a pulmonary exacerbation. Eur J Clin Nutr. 2012;66:1072-4 pubmed publisher
  4. Wilhelmsen K, Mesa K, Lucero J, Xu F, Hellman J. ERK5 protein promotes, whereas MEK1 protein differentially regulates, the Toll-like receptor 2 protein-dependent activation of human endothelial cells and monocytes. J Biol Chem. 2012;287:26478-94 pubmed publisher
  5. Drannik A, Nag K, Yao X, Henrick B, Sallenave J, Rosenthal K. Trappin-2/elafin modulate innate immune responses of human endometrial epithelial cells to PolyI:C. PLoS ONE. 2012;7:e35866 pubmed publisher
  6. Zhang J, Shan L, Koussih L, Redhu N, Halayko A, Chakir J, et al. Pentraxin 3 (PTX3) expression in allergic asthmatic airways: role in airway smooth muscle migration and chemokine production. PLoS ONE. 2012;7:e34965 pubmed publisher
  7. Arndts K, Deininger S, Specht S, Klarmann U, Mand S, Adjobimey T, et al. Elevated adaptive immune responses are associated with latent infections of Wuchereria bancrofti. PLoS Negl Trop Dis. 2012;6:e1611 pubmed publisher
  8. Suh H, Choi N, Tarassishin L, Lee S. Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12). PLoS ONE. 2012;7:e35115 pubmed publisher
  9. Berthelot L, Papista C, Maciel T, Biarnes-Pelicot M, Tissandié E, Wang P, et al. Transglutaminase is essential for IgA nephropathy development acting through IgA receptors. J Exp Med. 2012;209:793-806 pubmed publisher
  10. Kuo H, Yang Y, Chuang J, Tiao M, Yu H, Huang L, et al. Inflammation-induced hepcidin is associated with the development of anemia and coronary artery lesions in Kawasaki disease. J Clin Immunol. 2012;32:746-52 pubmed publisher
  11. van de Veerdonk F, Stoeckman A, Wu G, Boeckermann A, Azam T, Netea M, et al. IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist. Proc Natl Acad Sci U S A. 2012;109:3001-5 pubmed publisher
  12. Bellini A, Marini M, Bianchetti L, Barczyk M, Schmidt M, Mattoli S. Interleukin (IL)-4, IL-13, and IL-17A differentially affect the profibrotic and proinflammatory functions of fibrocytes from asthmatic patients. Mucosal Immunol. 2012;5:140-9 pubmed publisher
  13. Wilhelmsen K, Mesa K, Prakash A, Xu F, Hellman J. Activation of endothelial TLR2 by bacterial lipoprotein upregulates proteins specific for the neutrophil response. Innate Immun. 2012;18:602-16 pubmed publisher
  14. Marcondes A, Li X, Tabellini L, Bartenstein M, Kabacka J, Sale G, et al. Inhibition of IL-32 activation by α-1 antitrypsin suppresses alloreactivity and increases survival in an allogeneic murine marrow transplantation model. Blood. 2011;118:5031-9 pubmed publisher
  15. Lysaght J, van der Stok E, Allott E, Casey R, Donohoe C, Howard J, et al. Pro-inflammatory and tumour proliferative properties of excess visceral adipose tissue. Cancer Lett. 2011;312:62-72 pubmed publisher
  16. Elsawa S, Almada L, Ziesmer S, Novak A, Witzig T, Ansell S, et al. GLI2 transcription factor mediates cytokine cross-talk in the tumor microenvironment. J Biol Chem. 2011;286:21524-34 pubmed publisher
  17. Knobloch J, Hag H, Jungck D, Urban K, Koch A. Resveratrol impairs the release of steroid-resistant cytokines from bacterial endotoxin-exposed alveolar macrophages in chronic obstructive pulmonary disease. Basic Clin Pharmacol Toxicol. 2011;109:138-43 pubmed publisher
  18. Jensen G, Krause C, Sotzing G, Rusling J. Inkjet-printed gold nanoparticle electrochemical arrays on plastic. Application to immunodetection of a cancer biomarker protein. Phys Chem Chem Phys. 2011;13:4888-94 pubmed publisher
  19. Eikawa S, Ohue Y, Kitaoka K, Aji T, Uenaka A, Oka M, et al. Enrichment of Foxp3+ CD4 regulatory T cells in migrated T cells to IL-6- and IL-8-expressing tumors through predominant induction of CXCR1 by IL-6. J Immunol. 2010;185:6734-40 pubmed publisher
  20. Somerfield J, Hill-Cawthorne G, Lin A, Zandi M, McCarthy C, Jones J, et al. A novel strategy to reduce the immunogenicity of biological therapies. J Immunol. 2010;185:763-8 pubmed publisher
  21. Ikeda H, Hideshima T, Fulciniti M, Perrone G, Miura N, Yasui H, et al. PI3K/p110{delta} is a novel therapeutic target in multiple myeloma. Blood. 2010;116:1460-8 pubmed publisher
  22. Pennino D, Eyerich K, Scarponi C, Carbone T, Eyerich S, Nasorri F, et al. IL-17 amplifies human contact hypersensitivity by licensing hapten nonspecific Th1 cells to kill autologous keratinocytes. J Immunol. 2010;184:4880-8 pubmed publisher
  23. Khankin E, Mutter W, Tamez H, Yuan H, Karumanchi S, Thadhani R. Soluble erythropoietin receptor contributes to erythropoietin resistance in end-stage renal disease. PLoS ONE. 2010;5:e9246 pubmed publisher
  24. Hawn T, Scholes D, Wang H, Li S, Stapleton A, Janer M, et al. Genetic variation of the human urinary tract innate immune response and asymptomatic bacteriuria in women. PLoS ONE. 2009;4:e8300 pubmed publisher
  25. Khasraw M, Pavlakis N, McCowatt S, Underhill C, Begbie S, de Souza P, et al. Multicentre phase I/II study of PI-88, a heparanase inhibitor in combination with docetaxel in patients with metastatic castrate-resistant prostate cancer. Ann Oncol. 2010;21:1302-7 pubmed publisher
  26. Correale J, Farez M. Helminth antigens modulate immune responses in cells from multiple sclerosis patients through TLR2-dependent mechanisms. J Immunol. 2009;183:5999-6012 pubmed publisher
  27. Scutera S, Fraone T, Musso T, Cappello P, Rossi S, Pierobon D, et al. Survival and migration of human dendritic cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway. J Immunol. 2009;183:3004-13 pubmed publisher
  28. Christophi G, Panos M, Hudson C, Tsikkou C, Mihai C, Mejico L, et al. Interferon-beta treatment in multiple sclerosis attenuates inflammatory gene expression through inducible activity of the phosphatase SHP-1. Clin Immunol. 2009;133:27-44 pubmed publisher
  29. Damsgaard C, Lauritzen L, Calder P, Kjaer T, Frøkiaer H. Reduced ex vivo interleukin-6 production by dietary fish oil is not modified by linoleic acid intake in healthy men. J Nutr. 2009;139:1410-4 pubmed publisher
  30. Luo D, Fielding C, Phillips A, Fraser D. Interleukin-1 beta regulates proximal tubular cell transforming growth factor beta-1 signalling. Nephrol Dial Transplant. 2009;24:2655-65 pubmed publisher
  31. Aliahmadi E, Gramlich R, Grützkau A, Hitzler M, Krüger M, Baumgrass R, et al. TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23. Eur J Immunol. 2009;39:1221-30 pubmed publisher
  32. Huang Q, Sobkoviak R, Jockheck-Clark A, Shi B, Mandelin A, Tak P, et al. Heat shock protein 96 is elevated in rheumatoid arthritis and activates macrophages primarily via TLR2 signaling. J Immunol. 2009;182:4965-73 pubmed publisher
  33. Eid R, Rao D, Zhou J, Lo S, Ranjbaran H, Gallo A, et al. Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells. Circulation. 2009;119:1424-32 pubmed publisher
  34. Bender L, Thaarup J, Varming K, Krarup H, Ellermann-Eriksen S, Ebbesen F. Early and late markers for the detection of early-onset neonatal sepsis. Dan Med Bull. 2008;55:219-23 pubmed
  35. Hao Q, Wang L, Tang H. Vascular endothelial growth factor induces protein kinase D-dependent production of proinflammatory cytokines in endothelial cells. Am J Physiol Cell Physiol. 2009;296:C821-7 pubmed publisher
  36. Abolhassani M, Guais A, Chaumet-Riffaud P, Sasco A, Schwartz L. Carbon dioxide inhalation causes pulmonary inflammation. Am J Physiol Lung Cell Mol Physiol. 2009;296:L657-65 pubmed publisher
  37. Gupta S, Aranha C, Mohanty M, Reddy K. Toll-like receptors and cytokines as surrogate biomarkers for evaluating vaginal immune response following microbicide administration. Mediators Inflamm. 2008;2008:534532 pubmed publisher
  38. Zhao S, Gu Y, Dong Q, Fan R, Wang Y. Altered interleukin-6 receptor, IL-6R and gp130, production and expression and decreased SOCS-3 expression in placentas from women with pre-eclampsia. Placenta. 2008;29:1024-8 pubmed publisher
  39. Ahmed S, Marotte H, Kwan K, Ruth J, Campbell P, Rabquer B, et al. Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses transsignaling by enhancing soluble gp130 production. Proc Natl Acad Sci U S A. 2008;105:14692-7 pubmed publisher
  40. Correale J, Farez M, Razzitte G. Helminth infections associated with multiple sclerosis induce regulatory B cells. Ann Neurol. 2008;64:187-99 pubmed publisher
  41. Breitkreutz I, Raab M, Vallet S, Hideshima T, Raje N, Mitsiades C, et al. Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma. Leukemia. 2008;22:1925-32 pubmed publisher
  42. Novitskiy S, Ryzhov S, Zaynagetdinov R, Goldstein A, Huang Y, Tikhomirov O, et al. Adenosine receptors in regulation of dendritic cell differentiation and function. Blood. 2008;112:1822-31 pubmed publisher
  43. Weigert J, Neumeier M, Wanninger J, Wurm S, Kopp A, Schober F, et al. Reduced response to adiponectin and lower abundance of adiponectin receptor proteins in type 2 diabetic monocytes. FEBS Lett. 2008;582:1777-82 pubmed publisher
  44. Lamhamedi-Cherradi S, Martin R, Ito T, Kheradmand F, CORRY D, Liu Y, et al. Fungal proteases induce Th2 polarization through limited dendritic cell maturation and reduced production of IL-12. J Immunol. 2008;180:6000-9 pubmed
  45. Ishitsuka K, Hideshima T, Neri P, Vallet S, Shiraishi N, Okawa Y, et al. p38 mitogen-activated protein kinase inhibitor LY2228820 enhances bortezomib-induced cytotoxicity and inhibits osteoclastogenesis in multiple myeloma; therapeutic implications. Br J Haematol. 2008;141:598-606 pubmed publisher
  46. Kjellerup R, Kragballe K, Iversen L, Johansen C. Pro-inflammatory cytokine release in keratinocytes is mediated through the MAPK signal-integrating kinases. Exp Dermatol. 2008;17:498-504 pubmed
  47. Aydin S, Signorelli S, Lechleitner T, Joannidis M, Pleban C, Perco P, et al. Influence of microvascular endothelial cells on transcriptional regulation of proximal tubular epithelial cells. Am J Physiol Cell Physiol. 2008;294:C543-54 pubmed
  48. Weindl G, Naglik J, Kaesler S, Biedermann T, Hube B, Korting H, et al. Human epithelial cells establish direct antifungal defense through TLR4-mediated signaling. J Clin Invest. 2007;117:3664-72 pubmed
  49. Wu T, Xie C, Wang H, Zhou X, Schwartz N, Calixto S, et al. Elevated urinary VCAM-1, P-selectin, soluble TNF receptor-1, and CXC chemokine ligand 16 in multiple murine lupus strains and human lupus nephritis. J Immunol. 2007;179:7166-75 pubmed
  50. Gokhale R, Chandrashekara S, Vasanthakumar K. Cytokine response to strenuous exercise in athletes and non-athletes--an adaptive response. Cytokine. 2007;40:123-7 pubmed
  51. Breitkreutz I, Raab M, Vallet S, Hideshima T, Raje N, Chauhan D, et al. Targeting MEK1/2 blocks osteoclast differentiation, function and cytokine secretion in multiple myeloma. Br J Haematol. 2007;139:55-63 pubmed
  52. Birrell M, Catley M, Hardaker E, Wong S, Willson T, McCluskie K, et al. Novel role for the liver X nuclear receptor in the suppression of lung inflammatory responses. J Biol Chem. 2007;282:31882-90 pubmed
  53. Niemeyer C, Adler M, Wacker R. Detecting antigens by quantitative immuno-PCR. Nat Protoc. 2007;2:1918-30 pubmed
  54. Birrell M, Wong S, Catley M, Belvisi M. Impact of tobacco-smoke on key signaling pathways in the innate immune response in lung macrophages. J Cell Physiol. 2008;214:27-37 pubmed
  55. Poulain-Godefroy O, Froguel P. Preadipocyte response and impairment of differentiation in an inflammatory environment. Biochem Biophys Res Commun. 2007;356:662-7 pubmed
  56. Harding G, Mak Y, Evans B, Cheung J, MacDonald D, Hampson G. The effects of dexamethasone and dehydroepiandrosterone (DHEA) on cytokines and receptor expression in a human osteoblastic cell line: potential steroid-sparing role for DHEA. Cytokine. 2006;36:57-68 pubmed
  57. Kallio R, Sequeiros R, Surcel H, Ohtonen P, Kiviniemi H, Syrjala H. Early cytokine responses after percutaneous magnetic resonance imaging guided laser thermoablation of malignant liver tumors. Cytokine. 2006;34:278-83 pubmed
  58. Macagno A, Molteni M, Rinaldi A, Bertoni F, Lanzavecchia A, Rossetti C, et al. A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression. J Exp Med. 2006;203:1481-92 pubmed
  59. Peake N, Khawaja K, Myers A, Nowell M, Jones S, Rowan A, et al. Interleukin-6 signalling in juvenile idiopathic arthritis is limited by proteolytically cleaved soluble interleukin-6 receptor. Rheumatology (Oxford). 2006;45:1485-9 pubmed
  60. Birrell M, Wong S, Dekkak A, De Alba J, Haj-Yahia S, Belvisi M. Role of matrix metalloproteinases in the inflammatory response in human airway cell-based assays and in rodent models of airway disease. J Pharmacol Exp Ther. 2006;318:741-50 pubmed
  61. Hung M, Cherng W, Cheng C, Li L. Comparison of serum levels of inflammatory markers in patients with coronary vasospasm without significant fixed coronary artery disease versus patients with stable angina pectoris and acute coronary syndromes with significant fixed coronary artery diseas. Am J Cardiol. 2006;97:1429-34 pubmed
  62. Salaun B, Coste I, Rissoan M, Lebecque S, Renno T. TLR3 can directly trigger apoptosis in human cancer cells. J Immunol. 2006;176:4894-901 pubmed
  63. LeBouder E, Rey-Nores J, Raby A, Affolter M, Vidal K, Thornton C, et al. Modulation of neonatal microbial recognition: TLR-mediated innate immune responses are specifically and differentially modulated by human milk. J Immunol. 2006;176:3742-52 pubmed
  64. Karadag A, Zhou M, Croucher P. ADAM-9 (MDC-9/meltrin-gamma), a member of the a disintegrin and metalloproteinase family, regulates myeloma-cell-induced interleukin-6 production in osteoblasts by direct interaction with the alpha(v)beta5 integrin. Blood. 2006;107:3271-8 pubmed
  65. Lignell U, Meklin T, Putus T, Vepsäläinen A, Roponen M, Torvinen E, et al. Microbial exposure, symptoms and inflammatory mediators in nasal lavage fluid of kitchen and clerical personnel in schools. Int J Occup Med Environ Health. 2005;18:139-50 pubmed
  66. Fritz J, Girardin S, Fitting C, Werts C, Mengin-Lecreulx D, Caroff M, et al. Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists. Eur J Immunol. 2005;35:2459-70 pubmed
  67. Palmer G, Trolliet S, Talabot-Ayer D, Mezin F, Magne D, Gabay C. Pre-interleukin-1alpha expression reduces cell growth and increases interleukin-6 production in SaOS-2 osteosarcoma cells: Differential inhibitory effect of interleukin-1 receptor antagonist (icIL-1Ra1). Cytokine. 2005;31:153-60 pubmed
  68. Miranda-Carús M, Balsa A, Benito-Miguel M, Pérez de Ayala C, Martín-Mola E. IL-15 and the initiation of cell contact-dependent synovial fibroblast-T lymphocyte cross-talk in rheumatoid arthritis: effect of methotrexate. J Immunol. 2004;173:1463-76 pubmed
  69. Fusshoeller A, Plail M, Grabensee B, Plum J. Biocompatibility pattern of a bicarbonate/lactate-buffered peritoneal dialysis fluid in APD: a prospective, randomized study. Nephrol Dial Transplant. 2004;19:2101-6 pubmed
  70. Purokivi M, Hirvonen M, Roponen M, Randell J, Vahteristo M, Tukiainen H. Comparison of inflammatory elements in nasal lavage and induced sputum following occupational exposure to moldy-building microbes. Inhal Toxicol. 2002;14:653-62 pubmed
  71. Cheong Y, Laird S, Shelton J, Ledger W, Li T, Cooke I. The correlation of adhesions and peritoneal fluid cytokine concentrations: a pilot study. Hum Reprod. 2002;17:1039-45 pubmed
  72. Cheong Y, Shelton J, Laird S, Richmond M, Kudesia G, Li T, et al. IL-1, IL-6 and TNF-alpha concentrations in the peritoneal fluid of women with pelvic adhesions. Hum Reprod. 2002;17:69-75 pubmed
  73. Roponen M, Kiviranta J, Seuri M, Tukiainen H, Hirvonen M. Inflammatory mediators in nasal lavage, induced sputum and serum of employees with rheumatic and respiratory disorders. Eur Respir J. 2001;18:542-8 pubmed
  74. Purokivi M, Randell J, Hirvonen M, Tukiainen H. Reproducibility of measurements of exhaled NO, and cell count and cytokine concentrations in induced sputum. Eur Respir J. 2000;16:242-6 pubmed
more info or order :
company information
R and D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
800 343-7475
headquarters: USA