This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
BAG3
catalog :
10599-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation
citations: 43
Reference
McDermott Roe C, Lv W, Maximova T, Wada S, Bukowy J, Marquez M, et al. Investigation of a dilated cardiomyopathy-associated variant in BAG3 using genome-edited iPSC-derived cardiomyocytes. JCI Insight. 2019;4: pubmed publisher
Kulessa M, Weyer Menkhoff I, Viergutz L, Kornblum C, Claeys K, Schneider I, et al. An integrative correlation of myopathology, phenotype and genotype in late onset Pompe disease. Neuropathol Appl Neurobiol. 2019;: pubmed publisher
Klimek C, Jahnke R, Wördehoff J, Kathage B, Stadel D, Behrends C, et al. The Hippo network kinase STK38 contributes to protein homeostasis by inhibiting BAG3-mediated autophagy. Biochim Biophys Acta Mol Cell Res. 2019;1866:1556-1566 pubmed publisher
Mohseni Ahooyi T, Torkzaban B, Shekarabi M, Tahrir F, Decoppet E, Cotto B, et al. Perturbation of synapsins homeostasis through HIV-1 Tat-mediated suppression of BAG3 in primary neuronal cells. Cell Death Dis. 2019;10:473 pubmed publisher
Ghasemi Tahrir F, Gupta M, Myers V, Gordon J, Cheung J, Feldman A, et al. Role of Bcl2-associated Athanogene 3 in Turnover of Gap Junction Protein, Connexin 43, in Neonatal Cardiomyocytes. Sci Rep. 2019;9:7658 pubmed publisher
Chakraborty D, Felzen V, Hiebel C, Stürner E, Perumal N, Manicam C, et al. Enhanced autophagic-lysosomal activity and increased BAG3-mediated selective macroautophagy as adaptive response of neuronal cells to chronic oxidative stress. Redox Biol. 2019;24:101181 pubmed publisher
Ji C, Tang M, Zeidler C, Hohfeld J, Johnson G. BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processes. Autophagy. 2019;15:1199-1213 pubmed publisher
Fu H, Possenti A, Freer R, Nakano Y, Hernandez Villegas N, Tang M, et al. A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology. Nat Neurosci. 2019;22:47-56 pubmed publisher
Cheung J, Gordon J, Wang J, Song J, Zhang X, Prado F, et al. Mitochondrial dysfunction in human immunodeficiency virus-1 transgenic mouse cardiac myocytes. J Cell Physiol. 2019;234:4432-4444 pubmed publisher
Winter L, Unger A, Berwanger C, Sporrer M, Turk M, Chevessier F, et al. Imbalances in protein homeostasis caused by mutant desmin. Neuropathol Appl Neurobiol. 2018;: pubmed publisher
Clemen C, Winter L, Strucksberg K, Berwanger C, Türk M, Kornblum C, et al. The heterozygous R155C VCP mutation: Toxic in humans! Harmless in mice?. Biochem Biophys Res Commun. 2018;503:2770-2777 pubmed publisher
Hutt D, Mishra S, Roth D, Larsen M, Anglès F, Frizzell R, et al. Silencing of the Hsp70-specific nucleotide-exchange factor BAG3 corrects the F508del-CFTR variant by restoring autophagy. J Biol Chem. 2018;293:13682-13695 pubmed publisher
Jokl E, Hughes G, Cracknell T, Pownall M, Blanco G. Transcriptional upregulation of Bag3, a chaperone-assisted selective autophagy factor, in animal models of KY-deficient hereditary myopathy. Dis Model Mech. 2018;11: pubmed publisher
Schanzer A, Rupp S, Graf S, Zengeler D, Jux C, Akinturk H, et al. Dysregulated autophagy in restrictive cardiomyopathy due to Pro209Leu mutation in BAG3. Mol Genet Metab. 2018;123:388-399 pubmed publisher
Myers V, Tomar D, Madesh M, Wang J, Song J, Zhang X, et al. Haplo-insufficiency of Bcl2-associated athanogene 3 in mice results in progressive left ventricular dysfunction, β-adrenergic insensitivity, and increased apoptosis. J Cell Physiol. 2018;233:6319-6326 pubmed publisher
Tang M, Ji C, Pallo S, Rahman I, Johnson G. Nrf2 mediates the expression of BAG3 and autophagy cargo adaptor proteins and tau clearance in an age-dependent manner. Neurobiol Aging. 2018;63:128-139 pubmed publisher
Palucci I, Matic I, Falasca L, Minerva M, Maulucci G, De Spirito M, et al. Transglutaminase type 2 plays a key role in the pathogenesis of Mycobacterium tuberculosis infection. J Intern Med. 2018;283:303-313 pubmed publisher
Li C, Ming Y, Hong W, Tang Y, Lei X, Li X, et al. Comparison of hepatic transcriptome profiling between acute liver injury and acute liver failure induced by acetaminophen in mice. Toxicol Lett. 2018;283:69-76 pubmed publisher
Tahrir F, Shanmughapriya S, Ahooyi T, Knezevic T, Gupta M, Kontos C, et al. Dysregulation of mitochondrial bioenergetics and quality control by HIV-1 Tat in cardiomyocytes. J Cell Physiol. 2018;233:748-758 pubmed publisher
Sebastiani A, Gölz C, Sebastiani P, Bobkiewicz W, Behl C, Mittmann T, et al. Sequestosome 1 Deficiency Delays, but Does Not Prevent Brain Damage Formation Following Acute Brain Injury in Adult Mice. Front Neurosci. 2017;11:678 pubmed publisher
Li X, Hu Q, Chen L, Liu S, Su S, Tao H, et al. HSPB8 Promotes the Fusion of Autophagosome and Lysosome during Autophagy in Diabetic Neurons. Int J Med Sci. 2017;14:1335-1341 pubmed publisher
Cao Y, Yang Y, Mao C, Zhang X, Wang C, Yang J, et al. A role of BAG3 in regulating SNCA/?-synuclein clearance via selective macroautophagy. Neurobiol Aging. 2017;60:104-115 pubmed publisher
Judge L, Perez Bermejo J, Truong A, Ribeiro A, Yoo J, Jensen C, et al. A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress. JCI Insight. 2017;2: pubmed publisher
Park J, Park Y, Ryu I, Choi M, Lee H, Oh N, et al. Misfolded polypeptides are selectively recognized and transported toward aggresomes by a CED complex. Nat Commun. 2017;8:15730 pubmed publisher
Knezevic T, Myers V, Su F, Wang J, Song J, Zhang X, et al. Adeno-associated Virus Serotype 9 - Driven Expression of BAG3 Improves Left Ventricular Function in Murine Hearts with Left Ventricular Dysfunction Secondary to a Myocardial Infarction. JACC Basic Transl Sci. 2016;1:647-656 pubmed publisher
Ma K, Fu W, Tang M, Zhang C, Hou T, Li R, et al. PTK2-mediated degradation of ATG3 impedes cancer cells susceptible to DNA damage treatment. Autophagy. 2017;13:579-591 pubmed publisher
Liang J, Sagum C, Bedford M, Sidhu S, Sudol M, Han Z, et al. Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress. PLoS Pathog. 2017;13:e1006132 pubmed publisher
Su F, Myers V, Knezevic T, Wang J, Gao E, Madesh M, et al. Bcl-2-associated athanogene 3 protects the heart from ischemia/reperfusion injury. JCI Insight. 2016;1:e90931 pubmed publisher
Kathage B, Gehlert S, Ulbricht A, Lüdecke L, Tapia V, Orfanos Z, et al. The cochaperone BAG3 coordinates protein synthesis and autophagy under mechanical strain through spatial regulation of mTORC1. Biochim Biophys Acta Mol Cell Res. 2017;1864:62-75 pubmed publisher
Tahrir F, Knezevic T, Gupta M, Gordon J, Cheung J, Feldman A, et al. Evidence for the Role of BAG3 in Mitochondrial Quality Control in Cardiomyocytes. J Cell Physiol. 2017;232:797-805 pubmed publisher
Diaz Hidalgo L, Altuntas S, Rossin F, D Eletto M, Marsella C, Farrace M, et al. Transglutaminase type 2-dependent selective recruitment of proteins into exosomes under stressful cellular conditions. Biochim Biophys Acta. 2016;1863:2084-92 pubmed publisher
Sandell S, Huovinen S, Palmio J, Raheem O, Lindfors M, Zhao F, et al. Diagnostically important muscle pathology in DNAJB6 mutated LGMD1D. Acta Neuropathol Commun. 2016;4:9 pubmed publisher
Feldman A, Gordon J, Wang J, Song J, Zhang X, Myers V, et al. BAG3 regulates contractility and Ca(2+) homeostasis in adult mouse ventricular myocytes. J Mol Cell Cardiol. 2016;92:10-20 pubmed publisher
Ghaoui R, Palmio J, Brewer J, Lek M, Needham M, Evilä A, et al. Mutations in HSPB8 causing a new phenotype of distal myopathy and motor neuropathy. Neurology. 2016;86:391-8 pubmed publisher
Wang B, Yu X, Wang J, Li Z, Li P, Wang H, et al. Gold-nanorods-siRNA nanoplex for improved photothermal therapy by gene silencing. Biomaterials. 2016;78:27-39 pubmed publisher
Chevessier F, Schuld J, Orfanos Z, Plank A, Wolf L, Maerkens A, et al. Myofibrillar instability exacerbated by acute exercise in filaminopathy. Hum Mol Genet. 2015;24:7207-20 pubmed publisher
Cheung J, Gordon J, Wang J, Song J, Zhang X, Tilley D, et al. Cardiac Dysfunction in HIV-1 Transgenic Mouse: Role of Stress and BAG3. Clin Transl Sci. 2015;8:305-10 pubmed publisher
Vanoli A, Necchi V, Barozzi S, Manca R, Pecci A, Solcia E. Chaperone molecules concentrate together with the ubiquitin-proteasome system inside particulate cytoplasmic structures: possible role in metabolism of misfolded proteins. Histochem Cell Biol. 2015;144:179-84 pubmed publisher
Muñoz Moreno R, Barrado Gil L, Galindo I, Alonso C. Analysis of HDAC6 and BAG3-aggresome pathways in African swine fever viral factory formation. Viruses. 2015;7:1823-31 pubmed publisher
Ulbricht A, Gehlert S, Leciejewski B, Schiffer T, Bloch W, Höhfeld J. Induction and adaptation of chaperone-assisted selective autophagy CASA in response to resistance exercise in human skeletal muscle. Autophagy. 2015;11:538-46 pubmed publisher
Renziehausen J, Hiebel C, Nagel H, Kundu A, Kins S, Kögel D, et al. The cleavage product of amyloid-β protein precursor sAβPPα modulates BAG3-dependent aggresome formation and enhances cellular proteasomal activity. J Alzheimers Dis. 2015;44:879-96 pubmed publisher
Lei Z, Brizzee C, Johnson G. BAG3 facilitates the clearance of endogenous tau in primary neurons. Neurobiol Aging. 2015;36:241-8 pubmed publisher
Merabova N, Sariyer I, Saribas A, Knezevic T, Gordon J, Turco M, et al. WW domain of BAG3 is required for the induction of autophagy in glioma cells. J Cell Physiol. 2015;230:831-41 pubmed publisher
product information
CatalogNo :
10599-1-AP
AntigenName :
BAG3
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
BCL2-associated athanogene 3
Immunogen :
Recombinant Protein
Species :
hamster, human, monkey, mouse, rat
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, CO-IP, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
BAG 3, BAG3, BIS, CAIR 1, Docking protein CAIR 1
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC006418
Category :
Apoptosis;Binding Proteins;Disease Related;Metabolism;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IF 1:100 ; IHC 1:50 ; IP 1:1000 ; WB 1:5000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.