antibody

Mouse Monoclonal Antibody to GSK3 alpha

20089

100µl

monoclonal

mouse

nonconjugated

6G2F1

The same clone is also sold as:

• Abnova: MAB10671

western blot, ELISA, immunohistochemistry

Mouse Monoclonal Antibody to GSK3 alpha

Human

6G2F1;

100µl

4?; -20? for long term storage

GSK3 alpha (Glycogen synthase kinase 3 alpha), with 483-amino acid protein (about 53kDa), belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily,GSK3 subsubfamily, which also includes GSK3 beta.GSK3 is a multifunctional serine/threonine kinase that is usually inactivated by serine phosphorylation in response to extracellular cues. GSK3 is a key regulator of numerous signalling pathways, including cellular responses to Wnt, receptor tyrosine kinases and G-protein-coupled receptors and is involved in a wide range of cellular processes, ranging from glycogen metabolism to cell cycle regulation and proliferation.GSK3 alpha is implicated in the control of several regulatory proteins including glycogen synthase and transcription factors.

Purified recombinant fragment of GSK3 alpha expressed in E. Coli.

Ascitic fluid containing 0.03% sodium azide.

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000

1. Bradley W. Doble and James R. Woodgett. J. Cell Sci., Apr 2003; 116: 1175. ; 2. C. Laura Sayas , Aafke Ariaens, Bas Ponsioen. Mol. Biol. Cell, Apr 2006; 17: 1834 – 1844. ;

Monoclonal Antibody

DKFZp686D0638; GSK3A