product summary
request information :
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Rabbit Polyclonal LAMP-2/CD107b Antibody
catalog :
NBP1-71692
quantity :
0.05 ml
price :
299 USD
clonality :
polyclonal
host :
rabbit
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
publications citing this reagent :
  1. human (immunocytochemistry)
    Drivas T, Holzbaur E, Bennett J. Disruption of CEP290 microtubule/membrane-binding domains causes retinal degeneration. J Clin Invest. 2013;123:4525-39 pubmed publisher
more info or order :
Novus Biologicals product webpage
product information
Catalog Number :
NBP1-71692
Product Name :
Rabbit Polyclonal LAMP-2/CD107b Antibody
List Price :
299 USD
Product Type :
Primary Antibodies
Package Size :
0.05 ml
AltNames :
CD107 antigen-like family member B, CD107b, CD107b antigen, LAMP-2, LAMPB, LGP110, lysosomal-associated membrane protein 2, lysosome-associated membrane glycoprotein 2, Lysosome-associated membrane protein 2
Background :
LAMP2 is a member of a family of membrane glycoproteins. Because of its ability to confer selectins with carbohydrate ligands, it is related to tumor cell metastasis and autophagy. A lack or significant decrease in the prevalence of LAMP2 can lead to Danon's disease. This disease is characterized by the accumulation of autophagic material in striated myocytes. Finally, LAMP-2 immune reactions are related to focal necrotizing glomerulonephritis, a disease of the kidney.
Buffer :
PBS, 0.1% BSA, 50% glycerol
Clonality :
Polyclonal
Concentration :
0.2 mg/ml
Application Summary :
Western Blot, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin
Host :
Rabbit
Immunogen :
A genomic peptide made to an internal region of the human LAMP2 protein (within residues 250-400). [Swiss-Prot P13473]
Localization :
Cell membrane, Endosome membrane, Lysosome membrane.
Marker :
Late Endosome / Lysosome marker
Notes :
Manufactured by Genomic Antibody Technology . GAT FAQs
Preservative :
0.05% Sodium Azide
Purity :
Immunogen affinity purified
CrossReactivity :
Human and mouse. Immunogen has 94% identity to bovine, 92% to porcine, and 84% to rat.
Storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Swissprot Human :
P13473
Uses :
This LAMP2 antibody is useful for Immunocytochemistry/Immunofluorescence, Immunohistochemistry-paraffin embedded sections, and Western Blot. Immunoblot bands are seen ~40 kDa, 45 kDa and 110 kDa.The lower two bands represent the unglycosylated isoforms of LAMP2 while the 110 kDa band represents the glycosylated form. In ICC/IF, cytoplasmic lysosomal staining was observed in HeLa cells. In IHC-P, staining was observed in the cytoplasm of human kidney cells. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended
Research Area :
Cancer, Cellular Markers, Growth and Development, Lysosome Markers, Mast Cell Markers, Membrane Trafficking and Chaperones, Neuronal Cell Markers
References Product :
Drivas TG, Holzbaur EL, Bennett J et al. Disruption of CEP290 microtubule/membrane-binding domains causes retinal degeneration. J Clin Invest. 2013 Oct 1 [PMID: 24051377] (ICC/IF, Human)
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: USA
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.