product summary
request information :
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Rabbit Polyclonal GSK-3 beta Antibody
catalog :
NBP1-02156F
quantity :
0.1 ml
price :
299.00 USD
clonality :
polyclonal
host :
rabbit
conjugate :
FITC
reactivity :
human, mouse, rat, zebrafish
application :
western blot
more info or order :
Novus Biologicals product webpage
product information
Catalog Number :
NBP1-02156F
Product Name :
Rabbit Polyclonal GSK-3 beta Antibody
List Price :
299.00 USD
Product Type :
Primary Antibodies
Package Size :
0.1 ml
AltNames :
EC 2.7.11, EC 2.7.11.26, glycogen synthase kinase 3 beta, glycogen synthase kinase-3 beta, GSK-3 beta, GSK3beta isoform
Background :
Glycogen synthase kinase 3 (GSK3) is a proline-directed serine/threonine protein kinase that was originally identified for its role in glycogen metabolism; however, subsequently it was shown to serve pleiotropic functions, including embryonic development, gene transcription, and neuronal cell function. Mammalian GSK has two isoforms encoded by distinct genes: GSK3A produces a 51-kD GSK3-alpha protein and GSK3B a 47-kD GSK3-beta protein. Phosphorylation of Tyr279/Tyr216 on GSK3alpha/beta is important for enzymatic activity, whereas inactivation of GSK3 can be achieved through phosphorylation of Ser21/Ser9 residues within the N-terminal domain on GSK3-alpha/beta, respectively. Upstream kinases PKA, AKT/PKB, PKC, p90RSK/MAPKAP and p70S6K are known to phosphorylate Ser9 of GSK3-beta. Furthermore, GSK3 is also regulated via interactions with WNT ligand and its receptor Frizzled/co-receptor LRP5/6, and this interaction releases GSK3 from a multi-protein complex formed by beta-catenin, axin, and adenomatous polyposis coli (APC), which prevents GSK3-mediated beta-catenin degradation and induces beta-catenin-dependent gene transcription. GSK3 is one of the few signaling mediators that play central roles in a diverse range of signaling pathways, including those activated by WNT, hedgehog, growth factors, cytokines, and G protein-coupled ligands. GSK3 dysregulation, particularly hyperactivation, with various pathological conditions, including diabetes mellitus, obesity, inflammation, neurological disorders, and tumorigenesis.
Buffer :
50mM sodium borate
Clonality :
Polyclonal
Concentration :
1 mg/ml
Conjugate :
FITC
Application Summary :
Western Blot
Host :
Rabbit
Immunogen :
Synthetic peptide made to an internal portion of human GSK3 beta (within residues 1-100). [Swiss-Prot# P49841]
Preservative :
No Preservative
Purity :
Immunogen affinity purified
CrossReactivity :
Human. Predicted to react with rat, mouse, zebrafish and sheep based on 100% sequence homology.
Storage :
Store at 4C in the dark.
Swissprot Human :
P49841
TMW :
47 kDa
Uses :
This GSK3 beta antibody is useful for Immunocytochemistry/Immunofluorescence and Western blot, where a band is seen ~47 kDa. In ICC/IF strong cytoplasmic staining was observed.
Research Area :
Cancer, Hypoxia, Lipid and Metabolism, mTOR Pathway, Phospho Specific, Protein Kinase, Signal Transduction, Wnt Signaling Pathway
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: USA
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.