product summary
request information :
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Rabbit Polyclonal EGR2 Antibody
catalog :
NB110-59723R
quantity :
0.1 ml
price :
319.00 USD
clonality :
polyclonal
host :
rabbit
conjugate :
DyLight 550
reactivity :
human, rat
application :
western blot
more info or order :
Novus Biologicals product webpage
product information
Catalog Number :
NB110-59723R
Product Name :
Rabbit Polyclonal EGR2 Antibody
List Price :
319.00 USD
Product Type :
Primary Antibodies
Package Size :
0.1 ml
AltNames :
CMT1D, CMT4E, early growth response 2, early growth response 2 (Krox-20 homolog, Drosophila), early growth response protein 2, EGR-2, FLJ14547, Krox-20 homolog, Drosophila, KROX-20, Drosophila, homolog (early growth response-2), KROX20DKFZp686J1957, Zinc finger protein Krox-20, AT591
Background :
The EGR2 gene provides instructions for making a protein called early growth response 2, which is part of the early growth response family of proteins. These proteins bind to specific areas of DNA and help control the activity of particular genes. On the basis of this action, the proteins are referred to as transcription factors. The early growth response 2 protein activates several genes that are involved in the formation and maintenance of myelin, the fatty substance that covers and protects nerve cells. Myelin promotes the efficient transmission of nerve impulses. If myelin is lost (demyelination) or its structure is disrupted, the transmission of nerve impulses is impaired. Mutations in the EGR2 gene can cause two forms of Charcot-Marie-Tooth disease, type 1D or type 4E (sometimes called congenital hypomyelinating neuropathy) or a severe form of type 1D (sometimes called Dejerine-Sottas syndrome) that begins during infancy or early childhood.
Buffer :
50mM sodium borate
Clonality :
Polyclonal
Conjugate :
DyLight 550
Application Summary :
Western Blot
Host :
Rabbit
Immunogen :
A synthetic peptide made to a portion of human EGR2 (within residues 200-300). [Swiss-Prot# P11161]
Localization :
Nuclear
Preservative :
No Preservative
Purity :
Immunogen affinity purified
CrossReactivity :
Human and porcine. Immunogen sequence has 86% homology to mouse, rat, chicken and Xenopus proteins.
Storage :
Store at 4C in the dark.
Swissprot Human :
P11161
TMW :
50 kDa
Uses :
This EGR2 antibody is useful for Immunocytochemistry/Immunofluorescence and Western blot, where a band is seen at ~50 kDa. There is also a strong non-specific band at ~75 kDa. In ICC/IF nuclear staining was observed in Hela cells.
Research Area :
Chromatin Research, Neurodegeneration, Neuroscience, Transcription Factors and Regulators, Zinc Finger
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: USA
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.