catalog number :
MBS857045
products full name :
DNA PKcs (Phospho-Thr2609) antibody
products short name :
DNA PKcs
other names :
DNA-dependent protein kinase catalytic subunit isoform 2; DNA-dependent protein kinase catalytic subunit; DNA-dependent protein kinase catalytic subunit; p460; DNA-PK catalytic subunit; hyper-radiosensitivity of murine scid mutation, complementing 1; protein kinase, DNA-activated, catalytic polypeptide; DNPK1; p460
products gene name :
DNA PKcs
other gene names :
PRKDC; PRKDC; HYRC; p350; DNAPK; DNPK1; HYRC1; IMD26; XRCC7; DNA-PKcs; HYRC; HYRC1; DNA-PK catalytic subunit; DNA-PKcs
uniprot entry name :
PRKDC_HUMAN
specificity :
DNA PKcs (phospho-Thr2609) antibody detects endogenous levels of DNA PKcs only when phosphorylated at threonine 2609.
purity :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation
form :
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
concentration :
50ug/50ul
storage stability :
Store at -20 degree C for 1 year
tested application :
Western Blot (WB)
app notes :
WB: 1:500~1:1000
other info2 :
Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human DNA PKcs around the phosphorylation site of threonine 2609 (V-E-TP-Q-A). Pathway: Akt, CellCycle, DNA Damage/repair, Kinase/Phosphatases
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
products references :
Chan DW, et al. (2002) Genes Dev. Sep 15; 16(18): 2333-2338. Ding Q, et al. (2003) Mol Cell Biol. Aug; 23(16): 5836-5848. Douglas P, et al. (2002) Biochem J. Nov 15; 368(Pt 1): 243-251
ncbi acc num :
NP_001075109.1
ncbi gb acc num :
NM_001081640.1
ncbi mol weight :
465,501 Da
ncbi pathways :
BARD1 Signaling Events Pathway 137959!!Cell Cycle Pathway 198811!!Cell Cycle Pathway 83054!!Cell Cycle Pathway 463!!Class I PI3K Signaling Events Mediated By Akt Pathway 138020!!Coregulation Of Androgen Receptor Activity Pathway 138085!!Cytosolic Sensors Of Pathogen-associated DNA Pathway 576255!!DNA Repair Pathway 105837!!DNA-PK Complex Pathway 413430!!DNA-PK Complex Pathway 890556
ncbi summary :
This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]