catalog number :
MBS852529
products full name :
ABCD2 Antibody
products short name :
ABCD2
other names :
ATP-binding cassette sub-family D member 2; ATP-binding cassette sub-family D member 2; ATP-binding cassette sub-family D member 2; adrenoleukodystrophy-like 1; adrenoleukodystrophy-related protein; ATP-binding cassette, sub-family D (ALD), member 2; Adrenoleukodystrophy-like 1; Adrenoleukodystrophy-related protein; hALDR
products gene name :
ABCD2
other gene names :
ABCD2; ABCD2; ALDR; ABC39; ALDL1; ALDRP; hALDR; ALD1; ALDL1; ALDR; ALDRP; hALDR
uniprot entry name :
ABCD2_HUMAN
form :
Lyophilized anti-ABCD2 antibody purified by peptide affinity column containing 1% BSA and 0.02% NaN3
concentration :
100ug/200ul
storage stability :
Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at -20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.
tested application :
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)
app notes :
Peptide ELISA titer: 1:10,000-1:40,000. Western blot analysis: 1:500-1:1,000. Immunohistochemistry: 1:100-1:500. Optimal dilutions/concentrations should be determined by the end user.
other info1 :
Source Note: Rabbit polyclonal ABCD2 (1) antibody was raised against a peptide from C terminal residues of human ABCD2 protein. Reactivity Note: Not yet tested in other species.
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
ncbi acc num :
NP_005155.1
ncbi gb acc num :
NM_005164.3
ncbi mol weight :
83,233 Da
ncbi pathways :
ABC Transporters Pathway 83035!!ABC Transporters Pathway 436!!ABC-family Proteins Mediated Transport Pathway 106573!!ABCA Transporters In Lipid Homeostasis Pathway 477112!!Nuclear Receptors In Lipid Metabolism And Toxicity Pathway 198887!!Peroxisome Pathway 131226!!Peroxisome Pathway 131126!!Transmembrane Transport Of Small Molecules Pathway 106572
ncbi summary :
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis. [provided by RefSeq, Jul 2008]