This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
antibody
product name :
SPRY4, phosphorylated (Tyr75) (Protein Sprouty Homolog 4, Spry-4)
catalog :
MBS628687
quantity :
0.2 ml
price :
490 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
enzyme immunoassay, EMSA
product information
catalog number :
MBS628687
products type :
Antibody
products full name :
SPRY4, phosphorylated (Tyr75) (Protein Sprouty Homolog 4, Spry-4)
products short name :
SPRY4
products name syn :
Anti -SPRY4, phosphorylated (Tyr75) (Protein Sprouty Homolog 4, Spry-4)
other names :
SPRY4 protein; Protein sprouty homolog 4; protein sprouty homolog 4; spry-4; OTTHUMP00000160069; OTTHUMP00000222779; sprouty homolog 4 (Drosophila)
other gene names :
SPRY4; SPRY4
uniprot entry name :
SPY4_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Host: Rabbit; Source: Human
reactivity :
Human
specificity :
Recognizes human SPRY4 when phosphorylated at Tyr75.
purity :
Affinity Purified. Purified by Protein A affinity chromatography.
form :
Supplied as a liquid in PBS, 0.09% sodium azide.
storage stability :
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
tested application :
ELISA (EL/EIA), Gel Shift Assay (GS/EMSA)
app notes :
Suitable for use in ELISA and Dot Blot. Dilution: ELISA: 1:1,000. Dot Blot: 1:500
other info1 :
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Tyr75 of human SPRY4 (KLH).
products categories :
Antibodies; Abs to Sprouty
products description :
SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS activation and impairs the formation of active GTP-RAS.
ncbi gi num :
133777954
uniprot acc num :
Q9C004
ncbi mol weight :
32,541 Da
ncbi pathways :
Jak-STAT Signaling Pathway 83077!!Jak-STAT Signaling Pathway 488
ncbi summary :
SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002 [PubMed 12027893]).[supplied by OMIM]
uniprot summary :
Function: Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. Subunit structure: Interacts with the C-terminus of TESK1. Ref.1. Subcellular location: Cytoplasm. Cell projection ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Potential Ref.1. Domain: The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles. Sequence similarities: Belongs to the sprouty family.Contains 1 SPR (sprouty) domain. Sequence caution: The sequence AAK00652.1 differs from that shown. Reason: Erroneous initiation.
size :
0.2 ml
price :
490 USD
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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