14-3-3 theta (14-3-3 tau) | MyBioSource MBS603381 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

14-3-3 theta (14-3-3 tau)

catalog :

MBS603381

quantity :

0.05 mg

price :

370 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5J20

reactivity :

human, mouse, rat, cow

application :

western blot, ELISA, immunoprecipitation, enzyme immunoassay

product information

catalog number :

MBS603381

products type :

Antibody

products full name :

14-3-3 theta (14-3-3 tau)

products short name :

14-3-3 theta

products name syn :

Anti -14-3-3 theta (14-3-3 tau)

other names :

14-3-3 protein theta; 14-3-3 protein theta; 14-3-3 protein theta; protein tau; 14-3-3 protein tau; OTTHUMP00000015730; OTTHUMP00000165887; 14-3-3 protein T-cell; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide; 14-3-3 protein T-cell; 14-3-3 protein tau; Protein HS1

other gene names :

YWHAQ; YWHAQ; 1C5; HS1; 14-3-3

uniprot entry name :

1433T_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

5J20

host :

Mouse

reactivity :

Bovine, Human, Mouse, Rat

specificity :

Recognizes human 14-3-3 theta/tau. Does not crossreact with 14-3-3 zeta. 14-3-3 theta/tau is expressed by brain tissue and cells of the male germ line. Species Crossreactivity: mouse, rat and bovine.

purity :

Purified. Purified

form :

Supplied as a liquid in 20mM sodium phosphate, 150mM sodium chloride, pH 7.5, 0.08% sodium azide, 50% glycerol.

storage stability :

May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

tested application :

ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP)

app notes :

Suitable for use in Western Blot and Immunoprecipitation of both the native and denatured forms of the protein.

other info1 :

Immunogen: Recombinant 14-3-3 theta/tau (a single protein which is known by the alternative names 14-3-3 theta and 14-3-3 tau).

other info2 :

Hybridoma: Balb/c splenocytes. Positive Control: PC12 cells, 3T3 cells, MCBK cells, Jurkat cells, or normal human fibroblasts.

products categories :

Antibodies; Abs to 14-3-3

products description :

The 14-3-3 proteins are a family of homologous, evolutionarily conserved, acidic proteins expressed in all eukaryotes, with molecular masses ranging from 28-33kD. To date, seven different 14-3-3 isoforms have been identified in mammals, each encoded by a distinct gene. The expression of 14-3-3 isoforms is tissue specific and differentially regulated. The 14-3-3 proteins assemble into stable homo- and heterodimers, which modulate signaling cascades by binding to phosphorylated serine or threonine residues of target proteins. In addition to a phosphorylated serine or phohsphorylated threonine residue, 14-3-3 protein binding also requires an arginine located at position -3 or -4. The 14-3-3 proteins affect signaling in several manners, including: interfering with protein/protein interactions (example: 14-3-3's interference

ncbi gi num :

5803227

ncbi acc num :

NP_006817.1

ncbi gb acc num :

NM_006826.2

uniprot acc num :

P27348

ncbi mol weight :

27,764 Da

ncbi pathways :

Alpha6-Beta4 Integrin Signaling Pathway (198807); Calcium Regulation In The Cardiac Cell Pathway (198906); Cell Cycle Pathway (83054); Cell Cycle Pathway (463); Class I PI3K Signaling Events Mediated By Akt Pathway (138020); ErbB1 Downstream Signaling Pathway (138057); FoxO Family Signaling Pathway (138036); IL-3 Signaling Pathway (198881); Insulin-mediated Glucose Transport Pathway (137981); LKB1 Signaling Events Pathway (137957)

ncbi summary :

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq]

uniprot summary :

14-3-3 theta: a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes. Associates with c-BCR and BCR-Abl. Protein type: Adaptor/scaffold. Chromosomal Location of Human Ortholog: 2p25.1. Cellular Component: cytoplasmic vesicle membrane; focal adhesion; membrane; cytoplasm; cytosol. Molecular Function: protein domain specific binding; protein binding; protein N-terminus binding. Biological Process: substantia nigra development; apoptosis; small GTPase mediated signal transduction; negative regulation of transcription, DNA-dependent; protein targeting

size1 :

0.05 mg

price1 :

370 USD

size2 :

0.1 mg

price2 :

540