This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
antibody
product name :
CYP2D6 antibody
catalog :
MBS534692
quantity :
0.1 ml
price :
470 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
product information
catalog number :
MBS534692
products type :
Antibody
products full name :
CYP2D6 antibody
products short name :
CYP2D6
products name syn :
Polyclonal CYP2D6; Anti-CYP2D6; Cytochrome P450 2D6; CYPD6 -2; CYPD6 2; CYP2D6
other names :
cytochrome P450 2D6 isoform 1; Cytochrome P450 2D6; cytochrome P450 2D6; cytochrome P450, family 2, subfamily D, polypeptide 6; CYPIID6; Cytochrome P450-DB1; Debrisoquine 4-hydroxylase
products gene name :
CYP2D6
other gene names :
CYP2D6; CYP2D6; CPD6; CYP2D; CYP2DL1; CYPIID6; P450C2D; P450DB1; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; P450-DB1; CYP2DL1
uniprot entry name :
CP2D6_HUMAN
clonality :
Polyclonal
host :
Rabbit
reactivity :
To be determined by end-user
sequence length :
497
form :
Supplied as antiserum.
storage stability :
Aliquot and store at -20 degree C. Avoid repeated Freeze/Thaw cycles
tested application :
User optimized
other info1 :
Biological Significance: Cytochrome P450 2D6, a member of the cytochrome P450 mixed-function oxidase system, is one of the most important enzymes involved in the metabolism of xenobiotics in the body. Also, many substances are bioactivated by CYP2D6 to form their active compounds. While CYP2D6 is involved in the oxidation of a wide range of substrates of all the CYPs, there is considerable variability in its expression in the liver. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1.
other info2 :
Immunogen: CYP2D6 antibody was raised in rabbit using recombinant human P450 2D6 expressed in E Coli as the immunogen.
products categories :
Proteases, Inhibitors, & Enzymes
products description :
Rabbit polyclonal CYP2D6 antibody
ncbi gi num :
392513721
ncbi acc num :
NP_000097
ncbi gb acc num :
NM_000106.5
uniprot acc num :
P10635
ncbi mol weight :
50,061 Da
ncbi pathways :
Biological Oxidations Pathway 105698!!CYP2E1 Reactions Pathway 105705!!Codeine And Morphine Metabolism Pathway 198831!!Cytochrome P450 - Arranged By Substrate Type Pathway 105700!!Drug Metabolism - Cytochrome P450 Pathway 83032!!Drug Metabolism - Cytochrome P450 Pathway 427!!Fatty Acid Omega Oxidation Pathway 198915!!Fatty Acids Pathway 105706!!Metabolism Pathway 477135!!Metabolism Of Xenobiotics By Cytochrome P450 Pathway 83031
ncbi summary :
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
size :
0.1 ml
price :
470 USD
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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