MyBioSource

antibody

Myeloperoxidase antibody

MBS531881

1 mg

595 USD

monoclonal

mouse

human

western blot, enzyme immunoassay, ELISA

MBS531881

Antibody

Myeloperoxidase antibody

Myeloperoxidase

Monoclonal Myeloperoxidase; Anti-Myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase; Anti Myeloperoxidase; MPO; Myeloperoxidase; Myeloperoxidase light chainMyeloperoxidase heavy chain; MPO; 84 kDa myeloperoxidase; Myeloperoxidase light chainMyeloperoxidase heavy chain; 89 kDa myeloperoxidase; Myeloperoxidase; 89 kDa myeloperoxidase

myeloperoxidase; Myeloperoxidase; myeloperoxidase; myeloperoxidase; N/A

MPO; MPO; MPO

PERM_HUMAN

Monoclonal

IgG1

M05011922

Mouse

Human

Myeloperoxidase antibody was purified by chromatography on protein A Sepharose.

Purified IgG from Protein A Sepharose chromatography supplied in PBS, pH 7.4, with 0.1 % NaN3.

Store at 4 deg C.

ELISA (EIA), Western Blot (WB)

10-M92C can be sued as the coating antibody with 10-M92D as the detection antibody

Immunogen: Myeloperoxidase antibody was raised in mouse using human myeloperoxidase as the immunogen.

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.

Proteases, Inhibitors, Monoclonal Antibodies

Mouse monoclonal Myeloperoxidase antibody. Myeloperoxidase (MPO) is a peroxidase enzyme most abundantly present in neutrophil granulocytes (a subtype of white blood cells). It is a lysosomal protein stored in azurophilic granules of the neutrophil. MPO has a heme pigment, which causes its green color in secretions rich in neutrophils, such as pus and some forms of mucus.

4557759

NP_000241.1

NM_000250.1

P05164

83,869 Da

C-MYB Transcription Factor Network Pathway 138073!!Folate Metabolism Pathway 198833!!IL23-mediated Signaling Events Pathway 138000!!Phagosome Pathway 153910!!Phagosome Pathway 153859!!Selenium Pathway 198825!!Transcriptional Misregulation In Cancer Pathway 523016!!Transcriptional Misregulation In Cancer Pathway 522987!!Amb2 Integrin Signaling Pathway 137945

Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq, Jul 2008]

Function: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Catalytic activity: Cl- + H2O2 + H+ = HClO + H2O.Cl- + H2O2 = HOCl + 2 H2O. Cofactor: Binds 1 calcium ion per monomer.Binds 1 heme B (iron-protoporphyrin IX) group covalently per monomer. Subunit structure: Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain. Ref.13 Ref.20. Subcellular location: Lysosome. Involvement in disease: Defects in MPO are the cause of myeloperoxidase deficiency (MPOD) [. MIM:254600]. A disorder characterized by decreased myeloperoxidase activity in neutrophils and monocytes that results in disseminated candidiasis. Ref.23 Ref.24 Ref.25 Ref.26 Ref.27. Sequence similarities: Belongs to the peroxidase family. XPO subfamily.

1 mg

595 USD