This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
antibody
product name :
p53 antibody
catalog :
MBS531636
quantity :
0.1 mg
price :
550 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
DO-14
reactivity :
human
application :
western blot, immunohistochemistry, immunoprecipitation
product information
catalog number :
MBS531636
products type :
Antibody
products full name :
p53 antibody
products short name :
p53
products name syn :
Monoclonal p53; Anti-p53; p53 Oncoprotein; p53; p 53; p-53; BCC7; BOS_18908; brp53; cellular tumor antigen p53; drp53; EGK_08142; etID22686.5; fb40d06; LFS1; Li-Fraumeni syndrome; p53 tumor suppressor; p53 tumor suppressor phosphoprotein; phosphoprotein p53; transformation related protein 53; transformation-related protein 53; trp53; tumor protein 53; tumor protein p53 (Li-Fraumeni syndrome); tumor suppressing protein; tumor suppressor homolog p53; Tumor suppressor p53; tumor suppressor protein; tumor suppressor protein p53; tumor suppressor TP53; tumor supressor p53; Xp53
other names :
P53; Cellular tumor antigen p53; cellular tumor antigen p53; tumor protein p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53
products gene name :
p53
other gene names :
TP53; TP53; P53; BCC7; LFS1; TRP53; P53
uniprot entry name :
P53_HUMAN
clonality :
Monoclonal
isotype :
IgG1
clone :
DO-14
host :
Mouse
reactivity :
To be determined by end-user
sequence length :
393
specificity :
Human
purity :
p53 antibody was purified by Protein G affinity chromatography.
form :
Supplied as a liquid in PBS with 0.09% NaN3.
concentration :
1.0 mg/ml
storage stability :
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
tested application :
Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
app notes :
IHC-P: 1:1,000. WB: 1:1,000
other info1 :
Biological Significance: p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to mdm2, SV40 T antigen and human papilloma virus E6 protein p53 senses DNA damage and facilitates repair. Mutation involving p53 is found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
other info2 :
Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling. Immunogen: p53 antibody was raised in mouse using recombinant human p53 as the immunogen.
products categories :
Cancer
products description :
Mouse monoclonal p53 antibody
ncbi gi num :
23491729
ncbi acc num :
BAC16799.1
uniprot acc num :
P04637
ncbi mol weight :
24,401 Da
ncbi pathways :
AMPK Signaling Pathway 198868!!Activation Of BH3-only Proteins Pathway 105658!!Activation Of NOXA And Translocation To Mitochondria Pathway 105660!!Activation Of PUMA And Translocation To Mitochondria Pathway 105661!!Alzheimers Disease Pathway 672448!!Amyotrophic Lateral Sclerosis (ALS) Pathway 920975!!Amyotrophic Lateral Sclerosis (ALS) Pathway 83099!!Amyotrophic Lateral Sclerosis (ALS) Pathway 511!!Apoptosis Pathway 198797!!Apoptosis Pathway 83060
ncbi summary :
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013]
size :
0.1 mg
price :
550 USD
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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