antibody

MHC Class II antibody (FITC)

MBS530685

0.2 ml

535 USD

monoclonal

mouse

FITC

TDR31.1

western blot, flow cytometry, FACS

Antibody

MHC Class II antibody (FITC)

MHC Class II

Monoclonal MHC Class II; Anti-MHC Class II; MHC II; MHC Class II; Anti MHC Class II

MHC class II, partial; MHC class II HLA-DQ-beta-1; HLA class II histocompatibility antigen, DQ beta 1 chain; major histocompatibility complex, class II, DQ beta 1; MHC class II HLA-DQ-beta-1

HLA-DQB1; HLA-DQB1; IDDM1; CELIAC1; HLA-DQB

O19707_HUMAN

Monoclonal

IgG1

TDR31.1

Mouse

To be determined by end-user

229

Human

MHC Class II beta chain antibody (FITC) was purified by Protein A chromatography.

50mM Na3PO4, pH 7.5, with 100mM KCL, 150mM NaCl, 5% Glycerol, 0.2% BSA, and 0.04% NaN3.

0.25 mg/ml

Store at 4 degree C. DO NOT FREEZE.

Flow Cytometry (FC/FACS), Western Blot (WB)

FC: 5 ug/ml

Biological Significance: Human MHC Class II (HLA-DP, DQ & DR) molecules are expressed on dendritic cells, monocytes, macrophages, and myeloid cells. MHC Class II molecules are heterodimers of polymorphic transmembrane alpha and beta chains and generally bind exogenously derived peptides of about 10-17 amino acids. MHC Class II molecules interact with the T cell receptor on CD4+ T cells.

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Tag/Conjugate: FITC. Immunogen: MHC class II antibody (FITC) was raised in mouse using purified class II from JY cell line as the immunogen.

Immunology; Conjugated Monoclonal Antibodies

Mouse monoclonal MHC Class II antibody (FITC)

1160938

AAA85335.1

O19707

26,489 Da

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HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

0.2 ml

535 USD