This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
antibody
product name :
HLADR antibody (FITC)
catalog :
MBS530503
quantity :
100 Tests
price :
515 USD
clonality :
monoclonal
host :
mouse
conjugate :
FITC
reactivity :
human
application :
immunocytochemistry, flow cytometry, FACS
product information
catalog number :
MBS530503
products type :
Antibody
products full name :
HLADR antibody (FITC)
products short name :
HLADR
products name syn :
Monoclonal HLADR; Anti-HLADR; HLA DR; HLADR Class 11 B & T Subset; HLA-DR
other names :
HLA-DR, partial; HLA-DR; HLA class II histocompatibility antigen, DQ beta 1 chain; major histocompatibility complex, class II, DQ beta 1; HLA-DR
products gene name :
HLADR
other gene names :
HLA-DQB1; IDDM1; CELIAC1; HLA-DQB
uniprot entry name :
Q29900_HUMAN
clonality :
Monoclonal
isotype :
IgG1
clone :
1.00E+05
host :
Mouse
reactivity :
To be determined by end-user
sequence length :
42
form :
Liquid in 20mM TRIS, pH 8.0, with 150mM NaCl, and 10 mg BSA.
concentration :
0.2 mg/ml
storage stability :
Store at 4 degree C. DO NOT FREEZE. Keep away from light.
tested application :
Flow Cytometry (FC/FACS), Immunofluorescence (IF)
other info1 :
Biological Significance: HLA-DR is a major histocompatibility complex, MHC class II, cell surface receptor encoded by the human leukocyte antigen complex on chromosome 6 region 6p21.31. The complex of HLA-DR and its ligand, a peptide of 9 amino acids in length or longer, constitutes a ligand for the T-cell receptor (TCR). HLA (human leukocyte antigens) were originally defined as cell surface antigens that mediate graft-versus-host disease, which resulted in the rejection of tissue transplants in HLA-mismatched donors. Identification of these antigens has led to greater success and longevity in organ transplant.
other info2 :
Tag/Conjugate: FITC. Immunogen: HLADR antibody (FITC) was raised in mouse using cells of patient with acute lymphocytic leukemia of the c-ALL type as the immunogen.
products categories :
Immunology; Conjugated Monoclonal Antibodies
products description :
Mouse monoclonal HLADR antibody (FITC)
ncbi gi num :
642238
ncbi acc num :
CAA23788.1
uniprot acc num :
Q29900
ncbi mol weight :
29/34 kDa (predicted detection band MW)
ncbi pathways :
Adaptive Immune System Pathway 366160!!Allograft Rejection Pathway 920963!!Allograft Rejection Pathway 83123!!Allograft Rejection Pathway 535!!Antigen Processing And Presentation Pathway 83074!!Antigen Processing And Presentation Pathway 485!!Asthma Pathway 83120!!Asthma Pathway 532!!Autoimmune Thyroid Disease Pathway 83121!!Autoimmune Thyroid Disease Pathway 533
ncbi summary :
HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
size :
100 Tests
price :
515 USD
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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