MyBioSource

antibody

Anti-Human TLR2, Purified (Clone 11G7) (mouse IgG)

MBS520444

0.2 mg

295 USD

monoclonal

mouse

human

enzyme immunoassay, immunoprecipitation, immunohistochemistry, ELISA

MBS520444

Antibody

Anti-Human TLR2, Purified (Clone 11G7) (mouse IgG)

TLR2

TLR2, Purified (Clone 11G7) (mouse IgG); Anti-Human TLR2 (CD282) Monoclonal Antibody

toll-like receptor 2; Toll-like receptor 2; toll-like receptor 2; toll/interleukin 1 receptor-like 4; toll/interleukin-1 receptor-like protein 4; toll-like receptor 2; Toll/interleukin-1 receptor-like protein 4

TLR2

TLR2; TLR2; TIL4; CD282; TIL4

TLR2_HUMAN

Monoclonal

Mouse IgG1

IIG7

Mouse

Human

784

TLR2 (Human TLR2 (CD282))

Purified

1 mg/ml

For all formats, store at 4 degree C. DO NOT FREEZE PE conjugates. For long term storage (Purified, Biotin, FITC, No Azide), aliquot and freeze unused portion at -20 degree C in volumes appropriate for single usage. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC), Immunoprecipitation (IP), ELISA (EIA)

Immunogen: Human TLR2. Donor: mouse ascites fluid

Presentation: Purified IgG buffered in PBS and 0.02% NaN3. (Purified from ascitic fluid via Protein G Chromatography).

anti-human Toll-like Receptor 2 (TLR2) monoclonal antibody detects human TLR2 (CD282). This single membrane spanning, 784 amino acid, 90 KDa protein is a type of pattern recognition receptor (PRR) and recognizes structurally conserved microbial molecules as part of the innate immune response. TLR2 is activated in response to LPS (lipopolysaccharide) stimulation, resulting in NFkappaB activation and translocation. The TLR2 monoclonal antibody inhibits the production of inflammatory cytokines making it a selective inhibitor of TLR2 activation. TLR2 is expressed on peripheral blood macrophages, monocytes and leukocytes. This anti-body has been reported to work in Flow Cytometry, ELISA and Immunoprecipitation.

19718734

NP_003255.2

NM_003264.3

O60603

89,838 Da

Activated TLR4 Signalling Pathway 106400!!Amoebiasis Pathway 167324!!Amoebiasis Pathway 167191!!Beta Defensins Pathway 530759!!Chagas Disease (American Trypanosomiasis) Pathway 147809!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Defensins Pathway 530757!!Hepatitis B Pathway 694606!!Herpes Simplex Infection Pathway 377873!!Herpes Simplex Infection Pathway 377865

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq, Jul 2008]

Function: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6. Subunit structure: Interacts with LY96, TLR1 and TLR6 (via extracellular domain). Binds MYD88 (via TIR domain). Interacts with TICAM1. Ligand binding induces the formation of a heterodimer with TLR1 or TLR6. Interacts with CNPY3 . By similarity. Interacts with ATG16L1. Ref.10 Ref.12. Subcellular location: Membrane; Single-pass type I membrane protein . By similarity. Tissue specificity: Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues. Domain: Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12 . By similarity.The ATG16L1-binding motif mediates interaction with ATG16L1 (Ref.12). Post-translational modification: Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2. Polymorphism: Genetic variations in TLR2 are associated with susceptibility to leprosy [. MIM:246300]. Leprosy is a chronic disease associated with depressed cellular (but not humoral) immunity, the bacterium requires a lower temperature than 37 degrees Celsius and thrives particularly in peripheral Schwann cells and macrophages. The Trp-677 polymorphism in the intracellular domain of TLR2 has a role in susceptibility to lepromatous leprosy. Wild-type TLR2 mediates CD14-enhanced Mycobacterium leprae-dependent activation of NFKB1, but TLR2 containing the Trp-677 polymorphism did not. The impaired function of the Trp-677 polymorphism provides a molecular mechanism for the poor cellular immune response associated with lepromatous leprosy. Sequence similarities: Belongs to the Toll-like receptor family.Contains 19 LRR (leucine-rich) repeats.Contains 1 LRRCT domain.Contains 1 TIR domain.

0.2 mg

295 USD