Stat4 (C20) Antibody | MyBioSource MBS440028 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Stat4 (C20) Antibody

catalog :

MBS440028

quantity :

0.2 mg

price :

240 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunoprecipitation

product information

catalog number :

MBS440028

products type :

Antibody

products full name :

Stat4 (C20) Antibody

products short name :

STAT4

other names :

signal transducer and activator of transcription 4; Signal transducer and activator of transcription 4; signal transducer and activator of transcription 4; signal transducer and activator of transcription 4

products gene name :

STAT4

other gene names :

STAT4; STAT4; SLEB11

uniprot entry name :

STAT4_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Mouse, rat, human

sequence length :

748

specificity :

Mouse, rat and human Stat4

form :

200 ug/ml rabbit polyclonal IgG in 1 ml PBS containing 0.1 % sodium azide and 0.2% gelatin.

concentration :

0.200 mg/ml

storage stability :

Store this product at 4 degree C, do not freeze. The product is stable for one year from the date of shipment.

tested application :

Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)

app notes :

Western blotting starting dilution: 1:200.

other info1 :

Origin: Stat4 (C20) is provided as an affinity purified rabbit polyclonal antibody, raised against a peptide mapping to the carboxy terminus of mouse Stat 4.

other info2 :

Immunogen: Synthetic peptide mapping to the carboxy terminus of mouse Stat 4.

products description :

Signal Transducers and Activators of Transcription (STATs) are a family of cytoplasmic proteins that participate in cellular responses to cytokines and growth factors (1). Many cytokines involved in immune responses utilize the Jak-STAT signaling pathway. Jaks are receptor-associated protein tyrosine kinases, and STATs are activated by tyrosine phosphorylation (2). Abnormal signaling of the JAK-STAT pathway has been implicated in hematopoietic disorders including severe combined immunodeficiency and leukemia (4). STATs have been implicated in programming gene expression in biological events such as embryonic development, programmed cell death, organogenesis, innate immunity, adaptive immunity and cell growth regulation in many organisms (3). STAT1 knockout mice are defective in interferon-mediated functions. STAT4 and STAT6 knockout mice show defective responses to IL-12 and IL-4, respectively. Analyses of STAT5a and STAT5b knockout mice reveal important roles in prolactin-mediated mammary gland development and growth hormone-mediated induction of sexual dimorphism, respectively. Conditional knockout study of STAT3 demonstrates its critical roles in cytokine-mediated functions in several tissues, including T cells, macrophages, skin, and mammary gland (5). STAT6 and STAT4 are two STAT family members that specifically mediate signals from the IL-4 and IL-12 receptors, respectively (6).

products references :

1. Turkson J, Jove STAT proteins: novel molecular targets for cancer drug discovery. Oncogene. 2000 Dec 27; 19(56): 6613-26.2. Ivashkiv LB. Jak-STAT signaling pathways in cells of the immune system. Rev Immunogenet. 2000; 2(2): 220-303. Horvath CM. STAT proteins and transcriptional responses to extracellular signals. Trends Biochem Sci. 2000 Oct; 25(10): 496-502.4. Nosaka T, Kitamura T. Janus kinases (JAKs) and signal transducers and activators of transcription (STATs) in hematopoietic cells. Int J Hematol. 2000 Jun; 71(4): 309-19. 5. Takeda K, Akira S. STAT family of transcription factors in cytokine-mediated biological responses. Cytokine Growth Factor Rev. 2000 Sep; 11(3): 199-207.6. Wurster AL, Tanaka T, Grusby MJ. The biology of Stat4 and Stat6.Oncogene. 2000 May 15; 19(21): 2577-84.

ncbi gi num :

4507255

ncbi acc num :

NP_003142.1

ncbi gb acc num :

NM_003151.3

uniprot acc num :

Q14765

ncbi mol weight :

85,941 Da

ncbi pathways :

Downstream Signaling In Naive CD8+ T Cells Pathway 138018!!Hepatitis B Pathway 694606!!IL12 Signaling Mediated By STAT4 Pathway 137936!!IL12-mediated Signaling Events Pathway 137922!!IL23-mediated Signaling Events Pathway 138000!!IL27-mediated Signaling Events Pathway 137929!!Inflammatory Bowel Disease (IBD) Pathway 842771!!Inflammatory Bowel Disease (IBD) Pathway 842797!!Interferon Type I Pathway 920993!!JAK-STAT Signaling Pathway 1084760

ncbi summary :

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]

size :

0.2 mg

price :

240 USD