catalog number :
MBS421060
products full name :
Goat anti-ERK1 / MAPK3 Antibody
products short name :
ERK1/MAPK3
products name syn :
MAPK3; ERK1; mitogen-activated protein kinase 3; HGNC:6877; P44ERK1; P44MAPK; PRKM3; protein kinase; mitogen-activated 3 (MAP kinase 3 p44); HS44KDAP; HUMKER1A; MGC20180; OTTHUMP00000174538; extracellular signal-regulated kinase 1; extracellular signal-related kinase 1; MAPK3; ERK1; mitogen-activated protein kinase 3; HGNC:6877; P44ERK1; P44MAPK; PRKM3; protein kinase, mitogen-activated 3 (MAP kinase 3 p44); HS44KDAP; HUMKER1A; MGC20180; OTTHUMP00000174538; extracellular signal-regulated kinase 1; extracellular signal-related kinase 1
other names :
mitogen-activated protein kinase 3 isoform 1; Mitogen-activated protein kinase 3; mitogen-activated protein kinase 3; MAPK 1; MAP kinase isoform p44; insulin-stimulated MAP2 kinase; extracellular signal-related kinase 1; extracellular signal-regulated kinase 1; microtubule-associated protein 2 kinase; mitogen-activated protein kinase 3; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p44-ERK1
products gene name :
MAPK3
other gene names :
MAPK3; MAPK3; ERK1; ERT2; ERK-1; PRKM3; P44ERK1; P44MAPK; HS44KDAP; HUMKER1A; p44-ERK1; p44-MAPK; ERK1; PRKM3; MAP kinase 3; MAPK 3; ERK-1; p44-MAPK
uniprot entry name :
MK03_HUMAN
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx 45kDa band observed in Human Brain lysates, Kidney fibroblast HEK293 lysates and epidermoid fibroblast A431 lysates (calculated MW of 43.1kDa according to NP_002737.1). Recommended concentration: 0.1-0.3ug/ml. Peptide ELISA: antibody detection limit dilution 1:4000.
other info1 :
Epitope: N Terminus. Immunogen: Peptide with sequence GGEPRRTEGVGP-C, from the N Terminus of the protein sequence according to NP_002737.2; NP_001035145.1; NP_001103361.1. Corresponding Immunizing Peptide: Catalog #MBS426721
other info2 :
Important Note: No cross-reactivity expected with ERK2
ncbi acc num :
NP_002737.2
ncbi gb acc num :
NM_002746.2
ncbi mol weight :
40,088 Da
ncbi pathways :
AGE/RAGE Pathway 698754!!ALK1 Signaling Events Pathway 137968!!ARMS-mediated Activation Pathway 106466!!ATF-2 Transcription Factor Network Pathway 138006!!Activated TLR4 Signalling Pathway 106400!!Activation Of The AP-1 Family Of Transcription Factors Pathway 160139!!Acute Myeloid Leukemia Pathway 83117!!Acute Myeloid Leukemia Pathway 529!!Adherens Junction Pathway 83070!!Adherens Junction Pathway 481
ncbi summary :
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008]