catalog number :
MBS420181
products full name :
Goat anti-PAX8 (internal) Antibody
products short name :
PAX8
products name syn :
PAX8; paired box gene 8; HGNC:8622; paired domain gene 8; paired box 8; Goat Anti-PAX8 (N Terminus); PAX8; paired box gene 8; HGNC:8622; paired domain gene 8; paired box 8
other names :
paired box protein Pax-8 isoform PAX8A; Paired box protein Pax-8; paired box protein Pax-8; paired domain gene 8; paired box 8
products gene name :
PAX8
other gene names :
PAX8; PAX8
uniprot entry name :
PAX8_HUMAN
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB-Trf)
app notes :
Western Blot: In transfected HEK293 transiently expressing PAX8A a band of approx. 55kDa is observed. This band is not observed in the non-transfected HEK293. Recommended concentration: 0.5-1.5ug/ml. Peptide ELISA: antibody detection limit dilution 1:32000.
other info1 :
Epitope: Internal Region. Immunogen: Peptide with sequence C-AQPGSDKRKMDD, from the internal region of the protein sequence according to NP_003457.1; NP_039245.1; NP_039246.1; NP_039247.1; NP_054698.1. Corresponding Immunizing Peptide: Catalog #MBS426956
other info2 :
Important Note: This antibody is expected to recognise all reported isoforms (NP_003457.1; NP_039245.1; NP_039246.1; NP_039247.1; NP_054698.1)
ncbi acc num :
NP_003457.1
ncbi gb acc num :
NM_003466.3
ncbi mol weight :
31,044 Da
ncbi pathways :
Id Signaling Pathway 198871!!Pathways In Cancer 83105!!TSH Signaling Pathway 672446!!Thyroid Cancer Pathway 83112!!Thyroid Cancer Pathway 524!!Thyroid Hormone Synthesis Pathway 835410!!Thyroid Hormone Synthesis Pathway 839541!!Transcriptional Misregulation In Cancer Pathway 523016!!Transcriptional Misregulation In Cancer Pathway 522987
ncbi summary :
This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]